Zobrazeno 1 - 7
of 7
pro vyhledávání: '"George Kassiotis"'
Autor:
George Kassiotis
Our defenses against infection rely on the ability of the immune system to distinguish invading pathogens from self. This task is exceptionally challenging, if not seemingly impossible, in the case of retroviruses that have integrated almost seamless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0412d5178f41c37467be201a98b269e
Autor:
Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R. Young, Katey S.S. Enfield, Iker Valle Aramburu, Kevin W. Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterizes most cancer types, linked with disease outcomes. However, the underlying processes are incompletely understood. We show that elevated transcription of HE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f981cf8677b5246d4419e621d2a43568
Autor:
Kevin W. Ng, Nikhil Faulkner, Katja Finsterbusch, Mary Wu, Ruth Harvey, Saira Hussain, Maria Greco, Yafei Liu, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J. Gamblin, Peter Cherepanov, John McCauley, Rodney Daniels, Michael Howell, Hisashi Arase, Andreas Wack, David L.V. Bauer, George Kassiotis
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although antibody cross-reactivity with the spike glycoproteins (S) of diverse coronaviruse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9844eb0423388638674fe85eede9527e
Autor:
Annika Fendler, Scott T.C. Shepherd, Lewis Au, Mary Wu, Ruth Harvey, Katalin A. Wilkinson, Andreas M. Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe J. Queval, Caitlin Kavanagh, Emma C. Wall, Edward J. Carr, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O’Flaherty, Robyn L. Shea, Gail Gardner, Darren Murray, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J. Wilkinson, James Larkin, Samra Turajlic
Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886), we report immune responses in 80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02cc3c652d4326fd926337a398448a
Autor:
George Kassiotis, Rachel E. Rigby, Alain Townsend, Jan Rehwinkel, Anne Bridgeman, Tiong Kit Tan, Tanja Davis, George R. Young, Astrid Korning Hvidt, Qiannan Tang
Publikováno v:
Immunity
Summary Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an unusual left-handed double helix. Here, we studied the biological function(s) of Z-RNA recognition by the adenosine deaminase ADAR1, mutations in whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ac07ac811a028a34afa4f8b24ce6d7
Autor:
Nicola Ternette, George Kassiotis, David Perkins, Louise Hosie, Jonathan P. Stoye, Jan Attig, Vesela Encheva-Yokoya, Ambrosius P. Snijders, George R. Young
Dysregulated endogenous retroelements (EREs) are increasingly implicated in the initiation, progression, and immune surveillance of human cancer. However, incomplete knowledge of ERE activity limits mechanistic studies. By using pan-cancer de novo tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f4775308eb77875072803a5a8c5d34
Autor:
Jan Attig, Urszula Eksmond, Julia Merkenschlager, Pavel Tolar, Carla R. Nowosad, George Kassiotis, George R. Young, Luca Danelli
Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce837a9a575dc464ff0f7902193a2f3