Zobrazeno 1 - 10
of 858
pro vyhledávání: '"11"'
Autor:
G. Kloppel, R. Abs, F. R. Heller, E. Reyniers, Michel Meurisse, K. De Boulle, P. J. Willems, Albert Beckers, Achille Stevenaert
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 79:1498-1502
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited disorder characterized by nodular proliferation of the parathyroid glands and tumors of the anterior pituitary gland, the endocrine pancreas, and the neuroendocrine cell sy
Publikováno v:
Endocrinology. 136:4754-4761
11 beta-Hydroxysteroid dehydrogenase (11 beta HSD) catalyzes the conversion of corticosterone to inert 11-dehydrocorticosterone, thus regulating glucocorticoid access to intracellular receptors. This type 1 isoform (11 beta HSD-1) is a bidirectional
Autor:
Michael G. O'Rand, Gail Grossman, Perumal Sivashanmugam, Peter Petrusz, Yonglian Zhang, Rama Soundararajan, Katherine G. Hamil, Qiang Liu, Susan H. Hall, Frank S. French, Richard T. Richardson, Suresh Yenugu
Publikováno v:
Endocrinology. 143:2787-2796
Cystatin (CST)11, a novel member of the CST type 2 family of cysteine protease inhibitors, was identified in Macaca mulatta epididymis by subtractive hybridization cloning. The human CST11 gene on chromosome 20p11.2 is located near three other CST ge
Autor:
Maki Moritani, Toshiaki Sano, Takashi Yamaoka, Katsuhiko Yoshimoto, Chisato Tanaka, Takehiko Kimura, Mitsuo Itakura, Peng Yang, Shozo Yamada
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:2631-2634
To investigate the role of tumor suppressor genes in sporadic pituitary adenomas, we first analyzed loss of heterozygosity on 11q13 with microsatellite analysis in 31 tumors. Loss of heterozygosity on 11q13 was detected in 1 mixed GH/PRL adenoma, and
Autor:
Edward H. Oldfield, Sunita K. Agarwal, Robert J. Weil, Stephen J. Marx, Debra H. Schussheim, Monica C. Skarulis, Samuel M. Freedman, Svetlana Pack, Irina A. Lubensky, Zhengping Zhuang, Constantine A. Stratakis, Margaret F. Keil
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:4776-4780
Multiple endocrine neoplasia type 1 (MEN 1) is associated with parathyroid, enteropancreatic, pituitary, and other tumors. The MEN1 gene, a tumor suppressor, is located on chromosome 11. Affected individuals inherit a mutated MEN1 allele, and tumorig
Publikováno v:
Endocrinology. 141:3012-3019
The proliferation and differentiation of testicular progenitor stem cells into highly specialized germ cells (spermatozoa) are largely controlled by the hormonally (FSH and testosterone) regulated adjacent supporting Sertoli cells. However, the facto
Publikováno v:
Endocrinology. 138:4912-4920
Two types of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) have been identified in different tissues. Type 1 has both oxidase and reductase activities interconverting cortisol and cortisone, whereas type 2 has only oxidase activity converting co
Autor:
Ken Ichi Takahashi, Kouhei Fukushima, Hironobu Sasano, Robin E. Smith, Alicia N Stein-Oakley, Julie A. Maguire, Zygmunt S. Krozowski
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:3244-3248
The enzyme 11 beta-hydroxysteroid dehydrogenase type II (11 beta HSD2) confers specificity on the renal mineralocorticoid receptor by inactivating glucocorticoids. Mutations in this gene give rise to the syndrome of apparent mineralocorticoid excess,
Autor:
Tim J Cole
Publikováno v:
Endocrinology. 136:4693-4696
11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD2) protects mineralocorticoid receptors from high circulating levels of glucocorticoids and cDNAs for 11 beta-HSD2 from human and sheep have been recently cloned. We have isolated the gene for mouse
Publikováno v:
Endocrinology. 136:1759-1765
11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) protects the non-selective renal mineralocorticoid receptor from the endogeneous glucocorticoid cortisol. Thus, drugs inhibiting 11 beta-OHSD might enhance urinary loss of potassium. In an attempt t