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Publikováno v:
Langdahl, B L, Hofbauer, L C & Forfar, J C 2021, ' Cardiovascular Safety and Sclerostin Inhibition ', The Journal of clinical endocrinology and metabolism, vol. 106, no. 7, pp. 1845-1853 . https://doi.org/10.1210/clinem/dgab193
Sclerostin, which is primarily produced by the osteocytes, inhibits the canonical Wnt pathway and thereby the osteoblasts and stimulates RANKL release by the osteocytes and thereby osteoclast recruitment. Inhibition of sclerostin therefore causes sti
Autor:
Caro Minschart, Chantal Mathieu, Kyara De Weerdt, Christophe De Block, Astrid Elegeert, Sofie Vandeginste, Yves Jacquemyn, Paul Van Crombrugge, Johan Verhaeghe, Anne Loccufier, Carolien Moyson, Hilde Verlaenen, Katrien Benhalima, Annouschka Laenen, Chris Vercammen, Roland Devlieger, Toon Maes, Els Dufraimont, Annick Van den Bruel, Katrien De Clippel, Farah Mekahli
Publikováno v:
The journal of clinical endocrinology and metabolism
Aims To determine the impact of depressive symptoms on pregnancy outcomes and postpartum quality of life in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT). Methods 1843 women from a prospective cohort study received
Autor:
Marloes Nies, Mark Zafereo, Thera P. Links, Steven G. Waguespack, Sireesha Yedururi, Roland L. Bassett, Maria E. Cabanillas, Rena Vassilopoulou-Sellin, Steven I. Sherman
Publikováno v:
Journal of Clinical Endocrinology & Metabolism, 106(4), E1683-E1697. ENDOCRINE SOC
J Clin Endocrinol Metab
J Clin Endocrinol Metab
Context Distant metastases (DM) from childhood differentiated thyroid carcinoma (DTC) are uncommon and published studies are limited. Objective This work aimed to describe the outcomes of patients with DM from childhood DTC and to evaluate the molecu
Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-analysis
Autor:
Giovana Fagundes Piccoli, Cinara Stein, Fernando Gerchman, Maira Zoldan, Bernardo Frison Spiazzi, Gilberto de Lima Lopes Junior, Nathalia A H Degobi, Marina M Aziz, Verônica Colpani, Leonardo Mesquita
Publikováno v:
Journal of the Endocrine Society
Context Risk of cancer is a major concern in the development of drugs for the treatment of obesity and diabetes. In randomized controlled trials (RCTs) of the Liraglutide Clinical Development Program, subjects treated with a glucagon-like peptide-1 r
Autor:
Carol Chiung-Hui Peng, Sheng-Lun Kao, Kashif M. Munir, Huei-Kai Huang, Ching-Hui Loh, Yu-Kang Tu, Shu-Man Lin, Rachel Huai-En Chang, Tou-Yuan Tsai
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:2068-2080
Context The evidence of whether hypothyroidism increases mortality in the elderly population is currently inconsistent and conflicting. Objective The objective of this meta-analysis is to determine the impact of hypothyroidism on mortality in the eld
Autor:
Attila Gyenesei, Mikael Knip, Minna Kiviniemi, Taina Härkönen, Riitta Veijola, Witold Bauer, Jorma Ilonen, Johanna Lempainen, Jorma Toppari
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:4521-4530
Context Children with initial autoantibodies to either insulin (IAA) or glutamic acid decarboxylase (GADA) differ in peak age of seroconversion and have different type 1 diabetes (T1D) risk gene associations, suggesting heterogeneity in the disease p
Autor:
Sukran Yildirim, Evrim Kiray Bas, Firdevs Bas, Tulay Guran, Feyza Darendeliler, Asuman Coban, Banu Kucukemre Aydin, Nurçin Saka
Publikováno v:
Journal of the Endocrine Society
Context: Limited data are available on the exact incidence of disorders of sex development (DSD) with genital ambiguity at birth. Objective: To determine frequency of ambiguous genitalia in newborns. Design: Prospective multicenter study. Setting: Th
Autor:
Joan C. Lo, Jane A. Cauley, Gail A. Greendale, Carrie A. Karvonen-Gutierrez, Joel S. Finkelstein, Yinjuan Lian, Arun S. Karlamangla, Siobán D. Harlow, Sherri-Ann M. Burnett-Bowie, Kristine Ruppert
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:2412-2418
CONTEXT: Sex steroid hormones have been linked to fractures in older women. OBJECTIVE: To test the hypothesis that hormones measured over the menopausal transition predict fractures. SETTING: Seven US clinical centers. SUBJECTS AND MEASUREMENTS: Two
Autor:
Guangya Zhang, Yue-Yue Wan, Yu-Ru Ma, Jing Wu, Zheng Zhou, Rui-Jia Zhang, Fei-Fei Yuan, Shuang-Xia Zhao, Feng Sun, Dan Jiang, Qian-Yue Zhang, Lu Li, Xiao-Ping Ye, Ya Fang, Huai-Dong Song
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:2121-2130
CONTEXT Graves disease (GD) is a common thyroid-specific autoimmune disease and one of the most heritable diseases in the population. We present a risk-prediction model, including confirmed, known genetic variants associated with GD. DESIGN To constr
Autor:
Peter H. Bisschop, Maarten A. C. Broeren, Vincent W. V. Jaddoe, Eric A.P. Steegers, Yolanda B. de Rijke, Theo J Visser, Marco Medici, Tim I M Korevaar, Layal Chaker, Robin P Peeters, Tanja G. M. Vrijkotte, Victor J M Pop, Mariëtte Goddijn
Publikováno v:
Journal of clinical endocrinology and metabolism, 103(2), 778-789. The Endocrine Society
Journal of Clinical Endocrinology and Metabolism, 103, 778-789
Journal of Clinical Endocrinology and Metabolism, 103, 2, pp. 778-789
Journal of Clinical Endocrinology and Metabolism, 103(2), 778-789. Endocrine Society
Journal of Clinical Endocrinology and Metabolism, 103(2). ENDOCRINE SOC
Journal of Clinical Endocrinology and Metabolism, 103, 778-789
Journal of Clinical Endocrinology and Metabolism, 103, 2, pp. 778-789
Journal of Clinical Endocrinology and Metabolism, 103(2), 778-789. Endocrine Society
Journal of Clinical Endocrinology and Metabolism, 103(2). ENDOCRINE SOC
Objective To investigate a dose dependency of thyroperoxidase antibody (TPOAb) concentrations in relation to thyroid function and premature delivery and define a population-based, pregnancy-specific, functional cutoff for TPOAb positivity. Design Ind