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Publikováno v:
Molecular Endocrinology. 29:1123-1133
We have recently shown that angiotensin II-mediated uncoupling of endothelial nitric oxide synthase (eNOS) contributes to endothelial dysfunction in streptozotocin-induced type 1 diabetes mellitus. However, it has remained unclear whether and how eNO
Publikováno v:
Molecular Endocrinology. 20:1661-1672
Retinoid signaling is essential for development of vertebrate embryos, and its action is mainly through retinoic acid (RA) binding to its RA receptors and retinoid-X receptors, while the critical concentration and localization of RA in embryos are de
Autor:
Evangelia Charmandari, Emmanuil Souvatzoglou, Takamasa Ichijo, Alessandra Vottero, George P. Chrousos, Nisan Bhattacharyya, Tomoshige Kino
Publikováno v:
Molecular Endocrinology. 19:52-64
The human glucocorticoid receptor (hGR) beta, a splicing variant of the classic receptor hGRalpha, functions as a dominant-negative inhibitor of hGRalpha. We explored the mechanism(s) underlying this effect of hGRbeta by evaluating the interactions o
Publikováno v:
Molecular Endocrinology. 11:563-576
Glucocorticoids induce gene expression by binding to an intracellular receptor that interacts with genomic DNA and stimulates transcription of specific genes. The consensus DNA-binding site for the glucocorticoid receptor, called a glucocorticoid res
Autor:
Michael R. Stallcup, Janis L. Corey
Publikováno v:
Molecular Endocrinology. 6:450-458
Mouse lymphoma cell line W7MG1 is stably infected with mouse mammary tumor virus and produces the viral envelope glycoprotein precursor Pr74, but the mature envelope proteins gp52 and gp33, which are derived from Pr74 by posttranslational processing,
Autor:
Susan E. Sadler
Publikováno v:
Molecular Endocrinology. 5:1939-1946
Three phosphodiesterase (PDE) type III inhibitors were tested and found to inhibit Xenopus oocyte maturation induced by insulin with apparent IC50 values of 2.2 +/- 0.2 microM Cl-930, 25 +/- 3 microM imazodan (Cl-914), and 786 +/- 237 microM piroximo
Autor:
Lene J. Holland, Anuradha Bhattacharya
Publikováno v:
Molecular Endocrinology. 5:587-597
Fibrinogen synthesis is specifically induced by a synthetic glucocorticoid, dexamethasone, in primary liver parenchymal cell cultures of the frog Xenopus laevis. Here we demonstrate that this increase in the level of fibrinogen protein production is
Autor:
Ganesan Srinivasan, E B Thompson
Publikováno v:
Molecular Endocrinology. 4:209-216
We have expressed a full-length human glucocorticoid receptor (hGR) in Spodoptera frugiperda (Sf9) cells using the baculovirus expression vector system (BEVS). The level of expression is approximately 100-fold greater than in CEM-C7 cells. Between 0.
Publikováno v:
Molecular Endocrinology. 1:648-658
The actions of dexamethasone 21-mesylate (DM) have been studied in two recently developed cultured murine cell lines containing approximately 200 copies of episomal minichromosome. This minichromosome contains the glucocorticoid regulatory element in
Autor:
Carter Bancroft, Arthur E. Jackson
Publikováno v:
Molecular Endocrinology. 2:1139-1144
Previous investigations have shown that Ca2+ strongly and specifically stimulates endogenous PRL gene expression by GH3 cells. In this study, addition of Ca2+ to Ca2+-deprived GH3 cells yielded a large (ca. 8-fold) stimulation of transient expression