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Autor:
Serge Y. Fuchs, Xiaowei Xu, Angela K Brice, John M. Kirkwood, Qiujing Yu, J. Alan Diehl, Yuliya V. Katlinskaya, Daniel P. Beiting, Hallgeir Rui, Diwakar Davar, Kanstantsin V. Katlinski, Constantinos Koumenis, Cindy Sanders, Angelica Ortiz
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 171-180 (2016)
SummaryOncogene activation induces DNA damage responses and cell senescence. We report a key role of type I interferons (IFNs) in oncogene-induced senescence. IFN signaling-deficient melanocytes expressing activated Braf do not exhibit senescence and