Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rita, Guerreiro"'
Autor:
Vinod Udayar, Virginie Buggia-Prévot, Rita L. Guerreiro, Gabriele Siegel, Naresh Rambabu, Amanda L. Soohoo, Moorthi Ponnusamy, Barbara Siegenthaler, Jitin Bali, Mikael Simons, Jonas Ries, Manojkumar A. Puthenveedu, John Hardy, Gopal Thinakaran, Lawrence Rajendran, Rita Guerreiro, José Brás, Celeste Sassi, J. Raphael Gibbs, Dena Hernandez, Michelle K. Lupton, Kristelle Brown, Kevin Morgan, John Powell, Andrew Singleton
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1536-1551 (2013)
Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are membrane associated, but whether membrane tra
Autor:
Celeste, Sassi, Rita, Guerreiro, Raphael, Gibbs, Jinhui, Ding, Michelle K, Lupton, Claire, Troakes, Katie, Lunnon, Safa, Al-Sarraj, Kristelle S, Brown, Chirstopher, Medway, Jenny, Lord, James, Turton, David, Mann, Julie, Snowden, David, Neary, Jeniffer, Harris, Jose, Bras, Kevin, Morgan, John F, Powell, Andrew, Singleton, Clive, Holmes
Publikováno v:
Neurobiology of Aging
Early-onset Alzheimer's disease (EOAD) represents 1%–2% of the Alzheimer's disease (AD) cases, and it is generally characterized by a positive family history and a rapidly progressive symptomatology. Rare coding and fully penetrant variants in amyl