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Autor:
Koji Sawada, Katsuya Ikuta, Motohiro Shindo, Yasumichi Toki, Yutaka Kohgo, Takaaki Ohtake, Takumu Hasebe, Shunsuke Nakajima, Katsunori Sasaki, Hiroki Tanaka, Satoshi Ito, Yoshihiro Torimoto, Masayo Yamamoto, Mikihiro Fujiya, Mayumi Hatayama
Publikováno v:
Biochemical and Biophysical Research Communications. (4):501-507
Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorpt
Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorpt
Autor:
Bailong Xiao, Bertrand Coste, Manuela Schmidt, Adrienne E. Dubin, Ardem Patapoutian, Matthew J. Petrus, Jayanti Mathur
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2012, 2 (3), pp.511-517. ⟨10.1016/j.celrep.2012.07.014⟩
Cell Reports, Vol 2, Iss 3, Pp 511-517 (2012)
Cell Reports, 2012, 2 (3), pp.511-517. ⟨10.1016/j.celrep.2012.07.014⟩
Cell Reports, Elsevier Inc, 2012, 2 (3), pp.511-517. ⟨10.1016/j.celrep.2012.07.014⟩
Cell Reports, Vol 2, Iss 3, Pp 511-517 (2012)
Cell Reports, 2012, 2 (3), pp.511-517. ⟨10.1016/j.celrep.2012.07.014⟩
Heightened nociceptor function caused by inflammatory mediators such as bradykinin (BK) contributes to increased pain sensitivity (hyperalgesia) to noxious mechanical and thermal stimuli. Although it is known that sensitization of the heat transducer
Autor:
Go Suzuki, Naomi Oka, Keiji Mitani, Yasuo Mukai, Wataru Yamadera, Kazuya Shimada, Kazuhiro Kondo, Masashi Nibuya, Masayuki Iwashita, Nobuyuki Kobayashi, Ryo Aoki, Mayumi Takahashi, Kazuhiko Nakayama, Hiroshi Ito, Hirohiko Kuratsune, Shinichi Tokuno, Masaaki Tanichi
Publikováno v:
Biochemical and Biophysical Research Communications. (1):424-430
Fatigue reduces productivity and is a risk factor for lifestyle diseases and mental disorders. Everyone experiences physiological fatigue and recovers with rest. Pathological fatigue, however, greatly reduces quality of life and requires therapeutic
Publikováno v:
Biochemical and Biophysical Research Communications. (2):274-281
Biomarkers that are identified from a single study often appear to be biologically irrelevant or false positives. Meta-analysis techniques allow integrating data from multiple studies that are related but independent in order to identify biomarkers a
Publikováno v:
Biochemical and Biophysical Research Communications. (4):560-565
ApoA-I mimetics are short synthetic peptides that contain an amphipathic α-helix and stimulate cholesterol efflux by the ABCA1 transporter in a detergent-like extraction mechanism. We investigated the use of amphipathic peptides with a polypro helix
Autor:
Hironori Inaba, Hiroki Tanaka, Mitsuo Goto, Yoshihiro Nishida, Atsushi Enomoto, Hidemasa Goto, Kousuke Kasahara, Masaki Inagaki, Kenichi Kurita, Kaori Ushida, Yasuko Tomono, Hiroyuki Makihara
Publikováno v:
Biochemical and Biophysical Research Communications. (3):1323-1329
Desmin is a type III intermediate filament (IF) component protein expressed specifically in muscular cells. Desmin is phosphorylated by Aurora-B and Rho-kinase specifically at the cleavage furrow from anaphase to telophase. The disturbance of this ph
Publikováno v:
Biochemical and Biophysical Research Communications. (1):37-43
Cancer cells are mainly dependent on glycolysis to generate adenosine triphosphate (ATP) and intermediates required for cell growth and proliferation. Thus, inhibition of glycolysis might be of therapeutic value in antitumor treatment. Our previously
Publikováno v:
Biochemical and Biophysical Research Communications. (1):94-100
When the technology for constructing human antibody (Ab) libraries using a phage-display system was developed, many researchers in Ab-related fields anticipated that it would be widely applied to the development of pharmaceutical drugs against variou
Autor:
William A Nyberg, Alexander Espinosa
Publikováno v:
Biochemical and Biophysical Research Communications. (4):789-794
Endoplasmic reticulum (ER) stress is a physiological response to protein overload or misfolded proteins in the ER. Certain anti-cancer drugs, e.g. bortezomib and nelfinavir, induce ER stress implying that this could be a successful therapeutic strate