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Autor:
Shu-Hui Chuang, Doodipala Samba Reddy
Publikováno v:
J Pharmacol Exp Ther
Epilepsy is often treated with a combination of antiepileptic drugs. Although neurosteroids are potent anticonvulsants, little is known about their combination potential for the treatment of refractory epilepsy. Here, we investigated the combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c137fa5f7eb8a036391c85280e59d30
https://europepmc.org/articles/PMC7011113/
https://europepmc.org/articles/PMC7011113/
Publikováno v:
J Pharmacol Exp Ther
The kappa (κ) opioid receptor/dynorphin system modulates depression-like states and anhedonia, as well adaptations to stress and exposure to drugs of abuse. Several relatively short-acting small molecule κ-receptor antagonists have been synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c88c1fe6268fdda6a0470d0d40558c
https://europepmc.org/articles/PMC6538891/
https://europepmc.org/articles/PMC6538891/
Autor:
Songqi Gao, Beata Jastrzebska, Krzysztof Palczewski, Shirin Kahremany, Jianye Zhang, Janice Querubin, Simon M. Petersen-Jones
The retinoid (visual) cycle consists of a series of biochemical reactions needed to regenerate the visual chromophore 11-cis-retinal and sustain vision. Genetic or environmental factors affecting chromophore production can lead to blindness. Using an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4567285c145bb243a34584f68773e37
https://europepmc.org/articles/PMC5878677/
https://europepmc.org/articles/PMC5878677/
Autor:
Mary Jeanne Kreek, Eduardo R. Butelman, Michael J. Caspers, Kimberly M. Lovell, Thomas E. Prisinzano
Active blood-brain barrier mechanisms, such as the major efflux transporter P-glycoprotein (mdr1), modulate the in vivo/central nervous system (CNS) effects of many pharmacological agents, whether they are used for nonmedical reasons or in pharmacoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bf985593faf1244c2ee124087f56bb
https://europepmc.org/articles/PMC3362888/
https://europepmc.org/articles/PMC3362888/
Dysregulation of the 5-HT(2A) receptor is implicated in both the etiology and treatment of schizophrenia. Although the essential role of 5-HT(2A) receptors in atypical antipsychotic drug actions is widely accepted, the contribution of 5-HT(2A) down-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74743af2c11f176262ad4ef6a98c792
https://europepmc.org/articles/PMC3186284/
https://europepmc.org/articles/PMC3186284/
Autor:
Povl Krogsgaard-Larsen, Rasmus P. Clausen, Arne Schousboe, H. Steve White, Bjarke Ebert, Karsten K. Madsen
Modulation of the extracellular levels of GABA via inhibition of the synaptic GABA transporter GAT1 by the clinically effective and selective GAT1 inhibitor tiagabine [(R)-N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid; Gabitril] has proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0125046d9daa956427278ce467a0dda7
https://europepmc.org/articles/PMC3126646/
https://europepmc.org/articles/PMC3126646/
Very little is known about constitutive activity in vivo. This study examined whether constitutive activity and inverse agonism contribute to discriminative stimulus effects of drugs acting at serotonin (5-HT)(2A) receptors. Rats were trained to disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40623d8fb3513ce3f00c4db9415b2ddf
https://europepmc.org/articles/PMC2775261/
https://europepmc.org/articles/PMC2775261/