Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Richard A, Koup"'
Autor:
Rodrigo A Matus Nicodemos, David Ambrozak, Amy Ransier, Samuel Darko, Daniel C Douek, Richard A Koup
Publikováno v:
The Journal of Immunology. 206:20.17-20.17
Lentiviruses encode non-structural accessory proteins that function to counteract host restriction factors. The lentivirus protein Vpr is known to block G2 to M transition of the cell cycle and degrades various host DNA repair proteins, including UNG
Autor:
Karin Loré, Gunilla B. Karlsson Hedestam, Martina Soldemo, Anna Smed-Sörensen, Leif Perbeck, Mattias N. E. Forsell, Richard A. Koup, William C. Adams, Kerrie J. Sandgren, Richard T. Wyatt, Frank Liang
Publikováno v:
The Journal of Immunology. 191:60-69
Advances in HIV-1 vaccine clinical trials and preclinical research indicate that the virus envelope glycoproteins (Env) are likely to be an essential component of a prophylactic vaccine. Efficient Ag uptake and presentation by dendritic cells (DCs) i
Autor:
Robert A. Seder, Bernard Moss, Linda S. Wyatt, Patricia A. Darrah, Cecilia Morgan, Wing Pui Kong, Antonella Folgori, Ayako Yamamoto, Dana Berry, Mariano Esteban, Kylie M. Quinn, Lingshu Wang, Ross W. B. Lindsay, Jason G. D. Gall, Cheng Cheng, Robert T. Bailer, Richard A. Koup, Alfredo Nicosia, Carmen E. Gómez, Riccardo Cortese, Andreia Costa, David Price, Emma Gostick, Mario Roederer, Stefano Colloca, Gary J. Nabel
Publikováno v:
The Journal of Immunology. 190:2720-2735
Recombinant adenoviral vectors (rAds) are the most potent recombinant vaccines for eliciting CD8+ T cell–mediated immunity in humans; however, prior exposure from natural adenoviral infection can decrease such responses. In this study we show low s
Autor:
Viraj Kulkarni, David Price, J. Joseph Melenhorst, Daniel C. Douek, Jeffrey M. Jacobson, Constantinos Petrovas, George N. Pavlakis, Benjamin Chaon, David R. Ambrozak, Pratip K. Chattopadhyay, Mario Roederer, Yvonne M. Mueller, Peter D. Katsikis, Richard A. Koup, Joseph P. Casazza, Christof Geldmacher, Brenna J. Hill, Barbara K. Felber
Publikováno v:
The Journal of Immunology. 183:1120-1132
Recent studies have revealed the critical role of programmed death-1 (PD-1) in exhaustion of HIV- and SIV-specific CD8+ T cells. In this study, we show that high expression of PD-1 correlates with increased ex vivo spontaneous and CD95/Fas-induced ap
Autor:
Carolyn Williamson, Koleka Mlisana, Richard A. Koup, Mandla Mlotshwa, Salim S. Abdool Karim, Debra de Assis Rosa, Catherine Riou, Wendy A. Burgers, Clive M. Gray, Guy de Bruyn, Pholo Maenetje, Mario Roederer, Daniel C. Douek, Jason M. Brenchley
Publikováno v:
The Journal of Immunology. 182:4751-4761
Understanding early immunological events during HIV-1 infection that may set the course of disease progression is important for identifying correlates of viral control. This study explores the association of differentiation profiles of HIV-specific a
Autor:
Tao Dong, Toyin Togun, Hilton Whittle, Samuel J. McConkey, Assan Jaye, Melody G. Duvall, M A B van der Sande, Don Jeffries, Andrew J. McMichael, Sarah Rowland-Jones, Daniel C. Douek, Richard A. Koup, Abraham Alabi, Jason M. Brenchley
Publikováno v:
The Journal of Immunology. 176:6973-6981
Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross
Autor:
Mario Roederer, Fabien X. Lü, Richard A. Koup, Stephen P. Perfetto, Susan Moser, Joanne Yu, Judith Falloon, Christopher J. Miller, Thomas G. Evans, Stephen C. De Rosa
Publikováno v:
The Journal of Immunology. 173:5372-5380
In recent years, the quantification of T cell responses to pathogens or immunogens has become a common tool in the evaluation of disease pathogenesis or vaccine immunogenicity. Such measurements are usually limited to enumerating IFN-γ-producing cel
Autor:
John Hegarty, Daniel C. Douek, Jacinta Kelly, Cliona O'Farrelly, Richard A. Koup, Lucy Golden-Mason
Publikováno v:
The Journal of Immunology. 172:5980-5985
Normal adult human liver (AHL) contains populations of unconventional lymphocytes that have been shown in the mouse to mature locally. The presence of lymphoid progenitors together with IL-7, recombinase-activating gene, and pre-TCR-α expression in
Publikováno v:
The Journal of Immunology. 172:2219-2224
Langerhans cells (LC) are likely initial targets for HIV following sexual exposure to virus and provide an efficient means for HIV to gain access to lymph node T cells. The purpose of this study was to examine the nature of the CD4+ T cell that becom
Autor:
Elizabeth A. Thompson, Frank Liang, Gustaf Lindgren, Kerrie J. Sandgren, Kylie M. Quinn, Patricia A. Darrah, Richard A. Koup, Robert A. Seder, Ross M. Kedl, Karin Loré
Publikováno v:
The Journal of Immunology. 195:3497-3498