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Autor:
Sung-Sen Yang, Ann Chen, Ching-Liang Chu, Yu-Chuan Lin, Chung-Yao Wu, Shun-Min Yang, Feng-Cheng Liu, Shin-Ruen Yang, Shuk-Man Ka, Kuo-Feng Hua, Jack L. Arbiser
Publikováno v:
The Journal of Immunology. 204:1448-1461
Tris (dibenzylideneacetone) dipalladium (Tris DBA), a small-molecule palladium complex, has been shown to inhibit cell growth and proliferation in pancreatic cancer, lymphocytic leukemia, and multiple myeloma. In the current study, we examined the th
Autor:
Sanne H. Tonino, Stacey Tannheimer, Tom Hofland, Eric Eldering, Arnon P. Kater, Hanneke ter Burg, Renate de Boer, Iris de Weerdt
Publikováno v:
Journal of immunology (Baltimore, Md., 203(8), 2100-2109. American Association of Immunologists
Despite the emergence of small molecule inhibitors, current treatment strategies for chronic lymphocytic leukemia (CLL) are not curative, and the search for new therapeutic modalities continues. Prosurvival signaling derived from the microenvironment
Autor:
Yanni Lv, Pengyu Ma, Priyanka Pundir, Ting Lei, Fang Fang, Haiyan Dong, Shengli Han, Jue Wang, Langchong He, Tao Zhang, Tingting Zhao, Delu Che, Jiao Cao, Liu Rui, Nan Wang, Xinzhong Dong
Publikováno v:
The Journal of Immunology. 203:1701-1714
Intrathecal morphine infusion is often applied to treat chronic pain related to cancer and other conditions. However, persistent pain can be caused by nerve compression because of granuloma formation. In this study, a mouse model of morphine-induced
Autor:
Sina Weiss, Thomas M. Kündig, Agathe Duda, Isabella Dommann, Sandra N. Freiberger, Deborah S. Leuthard, Murray A. Skinner, Gabriele Fenini, Emmanuel Contassot, Pål Johansen, Matthias F. Kramer, Matthew D. Heath
Publikováno v:
The Journal of Immunology Author Choice
Allergen immunotherapy (AIT) is the only modality that can modify immune responses to allergen exposure, but therapeutic coverage is low. One strategy to improve AIT safety and efficacy is the use of new or improved adjuvants. This study investigates
Autor:
Norah A. Terrault, James C. Ryan, Lewis L. Lanier, Dennis J. Hartigan-O'Connor, M. Michele Manos, Joseph M. McCune, Gema Méndez-Lagares, Alexander Monto, Mandana Khalili, Connie Chen, Mark R. Segal, Hui Shen, Ding Lu
Publikováno v:
The Journal of Immunology. 200:1124-1132
The contribution of the host immune system to the efficacy of new anti-hepatitis C virus (HCV) drugs is unclear. We undertook a longitudinal prospective study of 33 individuals with chronic HCV treated with combination pegylated IFN-α, ribavirin, an
Autor:
Anna Reed, Ethan M. Sands, Anand Shah, Ali Abdolrasouli, Steven P. Templeton, Darius Armstrong-James, James E. Slaven, Nansalmaa Amarsaikhan
Publikováno v:
The Journal of Immunology. 199:624-632
The polysaccharide-rich fungal cell wall provides pathogen-specific targets for antifungal therapy and distinct molecular patterns that stimulate protective or detrimental host immunity. The echinocandin antifungal caspofungin inhibits synthesis of c
Autor:
Andrew Jerome, Pushpa Rao, Norma P. Gerard, Subhash Gaddipati, Bala Bharathi Burugula, Susmit Suvas
Publikováno v:
The Journal of Immunology. 197:4021-4033
Substance P neuropeptide and its receptor, neurokinin-1 receptor (NK1R), are reported to present on the ocular surface. In this study, mice lacking functional NK1R exhibited an excessive desquamation of apical corneal epithelial cells in association
Autor:
Jérémie Rossy, Nicodemus Tedla, Sarah E. Hancock, Zhengmin Yang, Abigail H. Pollock, Robert G. Parton, Maaike Kockx, Todd W. Mitchell, Rhea Cornely, Katharina Gaus
Publikováno v:
The Journal of Immunology. 196:3993-4002
Although it is recognized that lipids and membrane organization in T cells affect signaling and T cell activation, to what extent dietary lipids alter T cell responsiveness in the absence of obesity and inflammation is not known. In this study, we fe
Autor:
Leilani Zeumer, Seung Chul Choi, Byron P. Croker, Zhiwei Xu, Nathalie Kanda, Laurence Morel, Yiming Yin
Publikováno v:
The Journal of Immunology. 196:80-90
We have previously shown that CD4+ T cells from B6.Sle1Sle2.Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxy-d-glucose, which inhibits glucose metabolism, and metformin, which inhibits oxygen consumpt
Autor:
Brandon L. Logeman, Gunnar Pejler, Dennis J. Thiele, Helena Öhrvik, Glyn Noguchi, Inger Eriksson, Lena Kjellén
Publikováno v:
The Journal of Immunology. 195:3654-3664
Copper (Cu) is essential for multiple cellular functions. Cellular uptake of Cu+ is carried out by the Ctr1 high-affinity Cu transporter. The mobilization of endosomal Cu pools is regulated by a protein structurally similar to Ctr1, called Ctr2. It w