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Publikováno v:
The Journal of Immunology. 202:694-703
Many nonlymphoid cell types express at least two, if not all three, subunits of the IL-2R; although, compared with lymphocytes, relatively little is known about how IL-2 affects the function of nonlymphoid cells. The limited information available sug
Autor:
Auriel Dahan, Frédérique Lembo, Annie De Smet, Christine Bole-Feysot, Jean-Claude Weill, Damiana Lecoeuche, Nicolas Cagnard, Delphine Sterlin, Barbara Bertocci, Tatiana Fadeev, Baptiste Gaillard, Claude-Agnès Reynaud, Julius Kühn
Publikováno v:
The Journal of Immunology. 199:2408-2420
Klhl6 belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. Several of these proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex. In this article, we report tha
Autor:
Jinzhen Zhao, Menghao Li, Jichen Liu, Jing Hu, Tiantian Luo, Wenshuai He, Zhigang Guo, Dan Xi, Haowei Xiong, Hao Lu, Wenyan Lai
Publikováno v:
The Journal of Immunology. 197:3861-3870
Previously, we reported that heat shock protein (HSP)65 impairs the effects of high-density lipoprotein on macrophages. We also showed that immune response activation adversely affects reverse cholesterol transport (RCT). In this study, we investigat
Autor:
Don G. Lee, Su M. Shin, Sang H. Park, Young Ho Kim, Seung Jin Lee, Ho S. Oh, Chang H. Kim, Beom K. Choi, Byoung S. Kwon, Kwang Hyun Kim
Publikováno v:
The Journal of Immunology. 195:4721-4729
The glucocorticoid-induced TNFR family–related protein (GITR, TNFRSF18, CD357) is expressed on effector and regulatory T (Treg) cells. Previous studies demonstrated that GITR triggering by anti-GITR mAb enhanced T and B cell–mediated immune respo
Autor:
Amato de Paulis, Stefania Staibano, Massimo Mascolo, Pia Ragno, Nunzia Montuori, Marco Matucci-Cerinic, Loredana Postiglione, Gaetano Di Spigna, Serena Guiducci, Ada Pesapane, Gianni Marone, Francesca Wanda Rossi, Filomena Napolitano
Publikováno v:
Oncotarget
Systemic sclerosis (SSc) is characterized by chronic inflammation and fibrosis. N-Formyl peptide (fMLF) receptors (FPRs) are chemotactic receptors involved in inflammation. Three FPRs have been identified: FPR1, FPR2, and FPR3. We have examined, by R
Autor:
Ali Gawanbacht, Christof Kaltenmeier, Ramin Lotfi, Georg Härter, Manfred Hönig, Klaus Schwarz, Peter Kern, Timo Trzaska, Beate Grüner, Frank Kirchhoff, Hubert Schrezenmeier, Dorit Fabricius, Bernd Jahrsdörfer, Stefanie Lindner, Johannes A. van der Merwe, Catharina Schütz, Thamara Beyer, Ansgar Schulz, Martin Bommer
Publikováno v:
The Journal of Immunology. 194:3768-3777
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4+ T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine pr
Publikováno v:
The Journal of Immunology. 193:3378-3387
Endothelial cells closely interact with circulating lymphocytes. Aggression or activation of the endothelium leads to an increased shedding of endothelial cell microparticles (MP). Endothelial MP (EMP) are found in high plasma levels in numerous immu
Autor:
Shii-Yi Yang, Shin-Tang Su, Yi-Kai Chiu, Kuo-I Lin, I-Ying Lin, Kuan-Hsiung Wang, Yi-Ting Hsieh, Dong-Yan Tsai
Publikováno v:
The Journal of Immunology. 193:2207-2217
Ag-primed B cells that result from an immune response can form either memory B cells or Ab-secreting plasma cells; however, the molecular machinery that controls this cellular fate is poorly understood. In this study, we show that activated B cell fa
Autor:
Joung-Liang Lan, Ching-Yu Huang, Li-Li Chiu, Tse-Hua Tan, Der-Yuan Chen, Chia-Yu Yang, Huai-Chia Chuang, Ju-Pi Li
Publikováno v:
The Journal of Immunology. 192:1547-1557
T cell activation is dependent upon phosphorylation of MAPKs, which play a critical role in the regulation of immune responses. Dual-specificity phosphatase 14 (DUSP14; also known as MKP6) is classified as a MAPK phosphatase. The in vivo functions of
Publikováno v:
The Journal of Immunology. 192:1491-1501
Human bone marrow–derived mesenchymal stromal cells (MSCs) inhibit proliferation of activated T cells, and IFN-γ plays an important role in this process. This IFN-γ–licensed veto property is IDO-dependent. To further decipher the mechanistic un