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Publikováno v:
ImmunoHorizons. 4:597-607
The NKG2D ligand MHC class I chain–related protein A (MICA) is expressed on many varieties of malignant cells but is absent from most normal tissues, and thus represents a potential target for chimeric Ag receptor (CAR) T cell–based therapeutics.
Publikováno v:
The Journal of Immunology. 204:3400-3415
Mixed-lineage leukemia 1 (MLL1), which exerts its H3K4 methyltransferase activity by interacting with WDR5, ASH2L, and RBBP5, plays a pivotal role in regulating hematopoietic stem cell homeostasis. Disrupting the integrity of MLL1-complex has been re
Autor:
Minghong Xie, Mingjia Liu, Qiang Tong, Shuhong Wang, Yajing Lu, Jie Zhu, Feng Liu, Mingxuan Li, Xu Liu, Zhenping Ming, Mengling Ye, Rui Zhou
Publikováno v:
The Journal of Immunology. 203:1548-1559
Long noncoding RNAs are important regulators of gene expression in innate immune responses. Antisense IL-7 (IL-7–AS) is a newly discovered long noncoding RNA in human and mouse that has been reported to regulate the expression of IL-6. However, the
Publikováno v:
The Journal of Immunology. 203:1369-1382
Pyroptosis is a newly defined gasdermin (GSDM)-dependent inflammatory type of programmed cell death. Different from mammals, which have a panel of pyroptotic GSDM members (e.g., GSDMA–E), teleosts possess only GSDME. The pyroptotic activity and reg
Autor:
Wenxue Zhao, David J. Erle
Publikováno v:
The Journal of Immunology. 201:1053-1061
Chemokines are a large family of chemotactic cytokines that play critical roles in inflammation, development, and diseases. Chemokine expression is highly regulated during development and in response to environmental stimuli. The 3′ untranslated re
Autor:
Linda Vatan, Ke Wu, Ilona Kryczek, Joel Crespo, Tomasz Maj, Shuang Wei, Weiping Zou, Anthony W. Opipari, Wei Li
Publikováno v:
The Journal of Immunology. 201:814-820
Naive T cells are thought to be functionally quiescent. In this study, we studied and compared the phenotype, cytokine profile, and potential function of human naive CD4+ T cells in umbilical cord and peripheral blood. We found that naive CD4+ T cell
Autor:
Haiyan Wu, Sai-Juan Chen, Zhu Chen, Xin-Jie Chen, Qiu-Hua Huang, Jiang Zhu, Xiaodong Xi, Jin Liu, Tong Yin, Haimin Sun, Lie Ma, Xinlei Chen
Publikováno v:
The Journal of Immunology. 199:1817-1826
PALLD is an actin cross-linker supporting cellular mechanical tension. However, its involvement in the regulation of phagocytosis, a cellular activity essential for innate immunity and physiological tissue turnover, is unclear. We report that PALLD i
Autor:
Paul W. H. I. Parren, Frank J. Beurskens, Thomas Valerius, Ralf Schwanbeck, Annalina Tammen, Janine Schuurman, Thies Rösner, Anna Kretschmer, Stefanie Derer
Publikováno v:
The Journal of Immunology. 198:1585-1594
Triggering of the complement cascade induces tumor cell lysis via complement-dependent cytotoxicity (CDC) and attracts and activates cytotoxic cells. It therefore represents an attractive mechanism for mAb in cancer immunotherapy development. The cla
Autor:
Paul W. H. I. Parren, Ronald P. Taylor, Janine Schuurman, Erika M. Cook, Margaret A. Lindorfer, Clive S. Zent, Richard Burack, Hilma J. van der Horst, Frank J. Beurskens, Simone C. Oostindie
Publikováno v:
The Journal of Immunology. 197:1762-1775
Recently, we demonstrated that IgG Abs can organize into ordered hexamers after binding their cognate Ags expressed on cell surfaces. This process is dependent on Fc:Fc interactions, which promote C1q binding, the first step in classical pathway comp
Autor:
Don G. Lee, Su M. Shin, Sang H. Park, Young Ho Kim, Seung Jin Lee, Ho S. Oh, Chang H. Kim, Beom K. Choi, Byoung S. Kwon, Kwang Hyun Kim
Publikováno v:
The Journal of Immunology. 195:4721-4729
The glucocorticoid-induced TNFR family–related protein (GITR, TNFRSF18, CD357) is expressed on effector and regulatory T (Treg) cells. Previous studies demonstrated that GITR triggering by anti-GITR mAb enhanced T and B cell–mediated immune respo