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Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 12867-12879 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 12867-12879 (2021)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that causes tremors, gait rigidity, and hypokinesia. We determined the effects of long noncoding RNA small nucleolar RNA host gene 12 (lncRNA SNHG12) on the development of PD. Sta
Publikováno v:
Annals of Medicine
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Purpose During early embryo invasion (48 h after embryo attachment), what functional changes accompany dynamic gene expression alterations in human endometrial stromal cells? Method In the present study, primary human endometrial stromal cells (phESC
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8259-8278 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8259-8278 (2021)
Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The ‘classical’ role of APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins. Accordingly, AP1–3 are crucial for both vesicle formatio
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 6674-6686 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 6674-6686 (2021)
The purpose of this work is to probe into the potential role of long non-coding RNA growth arrest specific transcript 5 (lncGAS5)/ microRNA (miR)-188-5p/SMAD2 axis in MIRI. Through ligating the left anterior descending (LAD) coronary artery, MIRI ani
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8116-8124 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 8116-8124 (2021)
Necrotizing enterocolitis, a devastating gastrointestinal disease with high mortality, poses great threats to global health. Therefore, we conducted this study to explore the role of ANGPT2, as well as the potential mechanism, in necrotizing enteroco
Publikováno v:
Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Spike (S) glycoproteins mediate the coronavirus entry into the host cell. The S1 subunit of S-proteins contains the receptor-binding domain (RBD) that is able to recognize different host receptors, highlighting its remarkable capacity to adapt to the
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1572-1600 (2021)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1572-1600 (2021)
Lymphocyte-specific protein tyrosine kinase (Lck), a non-receptor Src family kinase, has a vital role in various cellular processes such as cell cycle control, cell adhesion, motility, proliferation, and differentiation. Lck is reported as a key fact
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3089-3100 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3089-3100 (2021)
It is found that the activation of Sonic Hedgehog (SHH) signaling pathway is related to the degree of inflammation in patients suffering from periodontitis. Cullin3 (CUL3), an important ubiquitin ligase, can control SHH signaling. In this study, we w
Publikováno v:
Drug Delivery
article-version (VoR) Version of Record
Drug Delivery, Vol 28, Iss 1, Pp 1237-1255 (2021)
article-version (VoR) Version of Record
Drug Delivery, Vol 28, Iss 1, Pp 1237-1255 (2021)
Nanotechnology provides synthetic carriers for cancer drug delivery that protect cargos from degradation, control drug release and increase local accumulation at tumors. However, these non-natural vehicles display poor tumor targeting and potential t
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3148-3158 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 3148-3158 (2021)
Dysregulation of long non-coding RNAs (lncRNAs) plays a fundamental role in the development and progression of osteoarthritis (OA), but the potential functions of lncRNAs in OA were not fully clarified. In the present work, we want to clarify the und