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Autor:
Miki Obata, Frank Löhr, Volker Dötsch, Natalia Yu. Rogova, Vladimir Kirkin, Ivan Dikic, Vladimir V. Rogov, Jens Gruber, Peter Güntert, Masato Akutsu, Jessica Huber, Masaaki Komatsu
Publikováno v:
Autophagy
Short linear motifs, known as LC3-interacting regions (LIRs), interact with mactoautophagy/autophagy modifiers (Atg8/LC3/GABARAP proteins) via a conserved universal mechanism. Typically, this includes the occupancy of 2 hydrophobic pockets on the sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e327642575fa140f4e6bc5616fb7c54
Autor:
Erinna F. Lee, Matthew A. Perugini, David W. Keizer, Brian J. Smith, Shenggen Yao, Marco Evangelista, Anne Pettikiriarachchi, Sharon Tran, Tatiana P. Soares da Costa, Nicholas A. Smith, W. Douglas Fairlie, Nastaran Meftahi, Tiffany J Harris
BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at threonine 108 (T108) within its BH3 domain blocks macroautophagy/autophagy by increasing BECN1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ace09c12d64fe26ac28ae44ff58f259
Selective macroautophagy/autophagy—with the help of molecular receptors—captures cargo for lysosomal degradation. Among the best-studied molecular receptors is SQSTM1/p62, a homo-oligomeric ubiquitin binding protein, which binds to both cargo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ab1df2c40a1c895321e2d9417a13e5
https://europepmc.org/articles/PMC5082789/
https://europepmc.org/articles/PMC5082789/
Autor:
Robert S Molday
A diffusion barrier segregates the plasma membrane of the rod photoreceptor outer segment into 2 domains; one which is optimized for the conductance of ions in the phototransduction cascade and another for disk membrane synthesis. We propose the form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d3ab333b493668ef1eff52b940d153
https://europepmc.org/articles/PMC4594370/
https://europepmc.org/articles/PMC4594370/
The interaction of p53 and MDM2 is modulated by the phosphorylation of p53. This mechanism is key to activating p53, yet its molecular determinants are not fully understood. To study the spatiotemporal characteristics of this molecular process we car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e995aad607dc4b997b0ecf8093f485a
https://europepmc.org/articles/PMC4353223/
https://europepmc.org/articles/PMC4353223/
Autor:
Antonio Díaz-Quintana, Isabel Cruz-Gallardo, Luis Alfonso Martínez-Cruz, Francisco J. Blanco, Alain Ibáñez de Opakua, Irene Díaz-Moreno, María L. Martínez-Chantar, Rafael Manfred Scheiba
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal and central domains (RRM1 and RRM2) are essential for AREs recognition, little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8730411ab54c09ca84b91b802e2012b