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Pyrrolizidine alkaloids (PAs) and their corresponding N-oxides (PANOs) have been determined in food and feed at levels relevant for consumer health. More than 660 different PAs have been detected, but few are available as reference substances for ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f76f5135585a5f6814737477a00b8b8
Autor:
Anna Vildhede, Takami Sarashina, Chester Costales, Sumathy Mathialagan, A. David Rodrigues, Nathaniel Johnson, Lydia M. M. Vermeer, Kenta Hashizume, Caleb D. Isringhausen, Andrea R. Wolff, Jillian G. Johnson, Laurie Tylaska, Emi Kimoto
1. Penciclovir, ganciclovir, creatinine, para-aminohippuric acid (PAH), ketoprofen, estrone 3-O-sulfate (E3S), dehydroepiandrosterone 3-O-sulfate (DHEAS) and cyclic guanosine monophosphate (cGMP) were screened as substrates of human liver organic ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e695772ae0303557d0dd7af4c251757f
Autor:
Sumiko Nakamura, Noriyuki Homma, Wataru Noro, Hisako Okumura, Ken'ichi Ohtsubo, Masayoshi Sugawara
We evaluated the effect of heat–moisture treatment (HMT) on the main chemical components, physical properties, and enzyme activities of two types of brown rice flour: high-amylose Koshinokaori and normal-quality Koshiibuki. Five different HMTs usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0cfc382a60a12d75242f8239b7e15d
Autor:
Myoung Soon Park, Hwa Jeong Lee, Joon Hun Choi, So-Jung Park, Young Jae An, Dae Kee Kim, Purushottam M. Dewang, Geunyoung Cha, Hyun Ju Park
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 702-712 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 702-712 (2020)
A series of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles, 7a–c, 11a–h, and 16a–h has been synthesised and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Incorporation of
Autor:
Sivia Bua, Alessio Nocentini, Ahmad J. Obaidullah, Hany E. A. Ahmed, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Mohamed M. Hefnawy, Nawaf A. Alsaif, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 598-609 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 598-609 (2020)
Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficien
Autor:
Daniel Jun, Eva Mezeiova, Rudolf Andrys, Jan Korabecny, Lukas Gorecki, Kamil Musilek, David Malinak, Miroslava Hozova, Veronika Racakova, Petr Bzonek, Kamil Kuca, Miroslav Psotka, Vendula Hepnarova, Rafael Dolezal
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Autor:
Claudiu T. Supuran, Pierluigi Caboni, Andrea Angeli, Elias Maccioni, Filippo Cottiglia, Mariella Nieddu, Claudia Sissi, Costantino Floris, Antonella Rosa, Benedetta Fois, Serenella Deplano, Rita Meleddu, Simona Distinto
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 539-548 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 539-548 (2020)
In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical invest
Autor:
Xu Zeping, Tian Yongqiang, Tian Jiewei, Yang Chuanlun, Dandan Yang, He Fuming, Zhang Xinqing, Chao Jin
In this study, a high protease-producing strain was screened by spread plate method and identified by molecular biology and morphological identification. It was identified as Bacillus sp. LCB14. A neutral protease gene was cloned and heterologous exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b284a7c2681703de73a236325b6615
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 726-732 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis. However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity. We used site-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb5a55a5e1fd311d579838e39d2136d
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1937-1943 (2020)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1937-1943 (2020)
Glycoside hydrolase family 18 (GH18) chitinases play an important role in various organisms ranging from bacteria to mammals. Chitinase inhibitors have potential applications as pesticides, fungicides, and anti-asthmatics. Berberine, a plant-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e46bc16fede1e54a5e721c55fded8a0