Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Henriette Heinrich, Matthias Sauter, Giancarlo Marra, Achim Weber, Hannah R Parker, Fabrizio Cereatti, Stephan R. Vavricka, Andreia Martinho Oliveira, Mark D. Robinson, Giulia Tanzi, Luca Albanese, Stephany Orjuela, Federico Buffoli, Paul Komminoth
Publikováno v:
Epigenetics
Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ˜20% of colon cancers with the CpG island methylator phenotype (CIMP), but their molecular features are poorly understood. We used high-throughput analysis of DNA methylati
Autor:
Judith Marsman, Euan J. Rodger, Victoria L Phillips, Basharat Bhat, Gregory T. Jones, Sally P.A. McCormick, Aniruddha Chatterjee, Michael J.A. Williams, Andre M. van Rij
Publikováno v:
Epigenetics
Changes in whole blood DNA methylation levels at several CpG sites have been associated with circulating blood lipids, specifically high-density lipoprotein and triglycerides. This study performs a discovery and validation epigenome-wide association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9f9242131f9d385f82d756687414e8
https://europepmc.org/articles/PMC7518699/
https://europepmc.org/articles/PMC7518699/
Autor:
Israel Fernandez-Cadenas, Jaume Roquer, Carolina Soriano-Tárraga, Eva Giralt-Steinhauer, Jordi Jimenez-Conde, Roberto Elosua, Angel Ois, Ana Rodríguez-Campello, Uxue Lazcano, C. Avellaneda-Gómez, Elisa Cuadrado-Godia, Manel Esteller, Natalia Cullell, Alba Fernández-Sanlés, Alejandra Gómez-González, Sebastian Moran, Joan Montaner
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Epigenetics
instname
Epigenetics
DNA methylation is dynamic, varies throughout the life course, and its levels are influenced by lifestyle and environmental factors, as well as by genetic variation. The leading genetic variants at stroke risk loci identified to date explain roughly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f1f9f1cace8f7a46fc210f1373c5a
http://hdl.handle.net/10261/235815
http://hdl.handle.net/10261/235815
Autor:
Paulina Kołodziej, Alina Kurylowicz, Anna Domaszewska-Szostek, Monika Puzianowska-Kuźnicka, Jacek Polosak, Magdalena Owczarz
Publikováno v:
Epigenetics
Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in SIRT6 expression in peripheral blood mononuclear c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a005e3d3e464b920c5ad2010ce2e436c
Autor:
Wei Zhao, Xiang Zhou, Farah Ammous, Jiaxuan Liu, Thomas H. Mosley, Jennifer A. Smith, Stephen T. Turner
Changes in DNA methylation may be a potential mechanism that mediates the effects of smoking on physiological function and subsequent disease risk. Given the dynamic nature of the epigenome, longitudinal studies are indispensable for investigating sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d687f4c7c45786a75c282b07adcc477c
Autor:
Gareth J.S. Jenkins, John Beynon, A. Paul Griffiths, Dean A. Harris, Jeremy Williamson, Namor Williams, HG Jones, Rory Kokelaar
DNA hypermethylation in gene promoter regions (CpG islands) is emerging as an important pathway in colorectal cancer tumourigenesis. Whilst genetic mutations have been associated with extramural vascular invasion (EMVI) in rectal cancer, no such asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe88299363f4861bdb7e2403f82d567
https://europepmc.org/articles/PMC5790361/
https://europepmc.org/articles/PMC5790361/
Autor:
Barry E. Storer, Jerry Davison, Xiaoyu Qu, Lisha G. Brown, Colm Morrissey, Min Fang, Robert L. Vessella, Yu Wu, Peter S. Nelson
To develop new methods to distinguish indolent from aggressive prostate cancers (PCa), we utilized comprehensive high-throughput array-based relative methylation (CHARM) assay to identify differentially methylated regions (DMRs) throughout the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70c574f6c394a1f0b64e05b1e1904b1
https://europepmc.org/articles/PMC4889305/
https://europepmc.org/articles/PMC4889305/
Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef9b886566627f745927ca5ddcab3b
Autor:
Victor Moreno, Mariona Bustamante, Juan R. González, Lucas A. Salas, Esther Gracia-Lavedan, Manolis Kogevinas, Cristina M. Villanueva
Trihalomethanes (THM) are undesired disinfection byproducts (DBPs) formed during water treatment. Mice exposed to DBPs showed global DNA hypomethylation and c-myc and c-jun gene-specific hypomethylation, while evidence of epigenetic effects in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb31c4cd16bd15b6ed1691182223059e
Age estimation from DNA methylation markers has seen an exponential growth of interest, not in the least from forensic scientists. The current published assays, however, can still be improved by lowering the number of markers in the assay and by prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3b366241cba8aceda240291d8dd744