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Autor:
Sze Hong Law, Wing-cheong Chan, Hela Koka, Cherry Wu, Lap Ah Tse, Amy Hutchinson, Maeve Kiely, Xiaohong R. Yang, Feng Wang, Han Zhang, Belynda Hicks, Koon Ho Tsang, Difei Wang, Bin Zhu, Eric Karlins, Priscilla Ming Yi Lee
Publikováno v:
Epigenetics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Age-related DNA methylation is a potential mechanism contributing to breast cancer development. Studies of primarily Caucasian women have identified many CpG sites of age-related methylation in non-diseased breast tissue possibly driving cancer devel
Autor:
Owen M. Wilkins, E. Andres Houseman, Kevin C. Johnson, Brock C. Christensen, Jessica E. King, Carmen J. Marsit
Publikováno v:
Epigenetics
Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation distinct from 5-methylcytosine (5mC), relatively little is known regarding the functions of 5hmC in mammalian tissues. To address this issue, we utilized a
Autor:
Henriette Heinrich, Matthias Sauter, Giancarlo Marra, Achim Weber, Hannah R Parker, Fabrizio Cereatti, Stephan R. Vavricka, Andreia Martinho Oliveira, Mark D. Robinson, Giulia Tanzi, Luca Albanese, Stephany Orjuela, Federico Buffoli, Paul Komminoth
Publikováno v:
Epigenetics
Sessile serrated adenomas/polyps (SSA/Ps) are the putative precursors of the ˜20% of colon cancers with the CpG island methylator phenotype (CIMP), but their molecular features are poorly understood. We used high-throughput analysis of DNA methylati
Autor:
Paulina Kołodziej, Alina Kurylowicz, Anna Domaszewska-Szostek, Monika Puzianowska-Kuźnicka, Jacek Polosak, Magdalena Owczarz
Publikováno v:
Epigenetics
Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in SIRT6 expression in peripheral blood mononuclear c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a005e3d3e464b920c5ad2010ce2e436c
Publikováno v:
Epigenetics
The development and progression of invasive breast cancer is characterized by alterations to the genome and epigenome. However, the relationship between breast tumor characteristics, disease subtypes, and patient outcomes with the cumulative burden o
Autor:
Gareth J.S. Jenkins, John Beynon, A. Paul Griffiths, Dean A. Harris, Jeremy Williamson, Namor Williams, HG Jones, Rory Kokelaar
DNA hypermethylation in gene promoter regions (CpG islands) is emerging as an important pathway in colorectal cancer tumourigenesis. Whilst genetic mutations have been associated with extramural vascular invasion (EMVI) in rectal cancer, no such asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe88299363f4861bdb7e2403f82d567
https://europepmc.org/articles/PMC5790361/
https://europepmc.org/articles/PMC5790361/
Autor:
Victor Moreno, Mariona Bustamante, Juan R. González, Lucas A. Salas, Esther Gracia-Lavedan, Manolis Kogevinas, Cristina M. Villanueva
Trihalomethanes (THM) are undesired disinfection byproducts (DBPs) formed during water treatment. Mice exposed to DBPs showed global DNA hypomethylation and c-myc and c-jun gene-specific hypomethylation, while evidence of epigenetic effects in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb31c4cd16bd15b6ed1691182223059e
Age estimation from DNA methylation markers has seen an exponential growth of interest, not in the least from forensic scientists. The current published assays, however, can still be improved by lowering the number of markers in the assay and by prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3b366241cba8aceda240291d8dd744
Autor:
Edwin K. Silverman, Weiliang Qiu, Jarrett D. Morrow, James D. Crapo, Michael H. Cho, Dawn L. DeMeo, Emily S. Wan
DNA methylation can be affected by systemic exposures, such as cigarette smoking and genetic sequence variation; however, the relative impact of each on the epigenome is unknown. We aimed to assess if cigarette smoking and genetic variation are assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de30edff5e3836b20d2ad1ab1b8fef8