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Publikováno v:
Annals of Medicine
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Aim MicroRNA-21 is an oncogenic miRNA that modulates the expression of multiple cancer-related target genes. We conducted this meta-analysis to assess diagnostic role of circulating miR-21 in CRC, hoping to choose the best biomarker in CRC diagnosis.
Autor:
Caj Haglund, Kaisa Ahopelto, Jaana Hagström, Camilla Böckelman, Reetta Peltonen, Helena Isoniemi
Publikováno v:
Cancer Biology & Therapy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Colorectal cancer (CRC) is the third most common cancer in the world. More than half of all affected patients develop liver metastases during the course of the disease, and over half experience recurrence despite radical primary surgery. Transketolas
Autor:
Yinxue Yang, Ningmei Zhang, Yong Du, Chun Yang, William C. Cho, Qi Fu, Dong Zhang, Xiaoming Liu
Objective: A microRNA (miRNA) that functionally downregulates the expression of tumor suppressors can be defined as an oncomir. Here, we interrogate the biological significance of miR-592 in colorectal cancer (CRC). Research design and methods: The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4623ec448d992a7829c0fb4f12106664
Publikováno v:
Cancer Biology & Therapy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Background Despite recent progress in screening survival-related genes, there have been few attempts to apply methods based on cancer stem cells (CSCs) for prognosis. We aimed to identify a CSC-based model to predict survival in colorectal cancer (CR
Programmed death 1 (PD-1) and its ligand PD-L1 play a key dysfunction of T lymphocytes. The purpose of this study was to assess and compare the prognostic role of tumor- TILs and its relationship with PD-L1 expression in stage II and III colon cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb957fdf2c470577024c44de4930cfe6
Background: Abnormal lipid metabolism is considered to be one of main promoters of colorectal cancer (CRC), and intestinal microorganisms may be involved in CRC in patients with abnormal lipid metabolism. Objective: To investigate lipid metabolism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96aa2207b057abaceba2a766915abbb
https://europepmc.org/articles/PMC6343685/
https://europepmc.org/articles/PMC6343685/
Tumors represent a dynamic system where the genomic plasticity permits to adapt to the perturbation induced by environmental pressures, supporting the importance of longitudinal tumor sampling strategies to deciphering the temporal acquisition of dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e4f5bced16ad6186b260c4ecb261e4
https://europepmc.org/articles/PMC6067891/
https://europepmc.org/articles/PMC6067891/
Autor:
Gareth J.S. Jenkins, John Beynon, A. Paul Griffiths, Dean A. Harris, Jeremy Williamson, Namor Williams, HG Jones, Rory Kokelaar
DNA hypermethylation in gene promoter regions (CpG islands) is emerging as an important pathway in colorectal cancer tumourigenesis. Whilst genetic mutations have been associated with extramural vascular invasion (EMVI) in rectal cancer, no such asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe88299363f4861bdb7e2403f82d567
https://europepmc.org/articles/PMC5790361/
https://europepmc.org/articles/PMC5790361/
Autor:
Yang Wang, Caixia Hu, Honghai Zhang, Bin Sun, Jiasheng Zheng, Qin-Sheng Shi, Wei Li, Haiyan Wang, Hui Chen, Jiang Long
To assess the efficacy of percutaneous thermal ablation in treating colorectal cancer liver metastases (CRCLM), and to propose a prognostic nomogram for overall survival (OS).Seventy-one patients with CRCLM undergoing thermal ablation at our institut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dee2c59b61005338e12a1d91cb5eb8
Autor:
Yoshihiko Segawa, Masato Nakamura, Wataru Ichikawa, Tadamichi Denda, Mitsugu Kochi, Masahito Kotaka, Masahiro Takeuchi, Toshifusa Nakajima, Masashi Fujii, Miriana Moran, Heinz-Josef Lenz, Takehiro Takahashi, Toshiki Masuishi, Shu Cao, Stephanie H. Astrow, Dongyun Yang, Yu Sunakawa, Craig Stephens, Ken Shimada, Wu Zhang, Akihito Tsuji
Several studies have reported that epidermal growth factor receptor (EGFR)-related molecules may serve as predictors of cetuximab treatment for metastatic colorectal cancer (mCRC), such as EGFR gene copy number (GCN), expression of 2 ligands of EGFR,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3326820077143b08abb9e44f18227763
https://europepmc.org/articles/PMC4970538/
https://europepmc.org/articles/PMC4970538/