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Publikováno v:
Glycoconjugate Journal
Furin is one of the nine-member proprotein convertase family. Furin cleaves proteins with polybasic residues, which includes many viral glycoproteins such as SARS-Cov-2 spike protein. The cleavage is required for the activation of the proteins. Curre
Autor:
Jun Guo, Noel Dybdal, Ben-Quan Shen, Daniela Bumbaca Yadav, Gail Lewis Phillips, William R Proctor, James R. Kiefer
Publikováno v:
Breast Cancer Research and Treatment
Purpose Assessment of non-clinical safety signals relies on understanding species selectivity of antibodies. This is particularly important with antibody–drug conjugates, where it is key to determine target-dependent versus target-independent toxic
Publikováno v:
Medicinal Chemistry Research
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA) are primary causes of skin and soft tissue infections worldwide. To address the emergency caused due to increasing multidrug-resistant (MDR) bact
Autor:
Giuseppe Lippi, Maria Helena Santos de Oliveira, Ivan Szergyuk, Brandon Michael Henry, Justin L. Benoit, Stefanie W. Benoit, Emmanuel J. Favaloro
Publikováno v:
Journal of Thrombosis and Thrombolysis
Lipoprotein(a) (Lp(a)) is a prothrombotic and anti-fibrinolytic lipoprotein, whose role has not been clearly defined in the pathogenesis of coronavirus disease 2019 (COVID-19). In this prospective observational study, serum Lp(a) as well as outcomes
Autor:
Guowei Zhang, Hua Yang, Min Xie, Pengwei Zhang, Jian-Xian Luo, Zhisheng Ji, Hongsheng Lin, Jing Zhang, Yang Wang
Publikováno v:
Journal of Molecular Neuroscience
Loss of physical and emotional health due to spinal cord injury (SCI) has been rapidly increasing worldwide. Effective evaluation of the severity of SCI is crucial to its prognosis. Herein, we constructed rat models of SCI with four different degrees
Publikováno v:
Breast Cancer Research and Treatment
PurposeMenopause is associated with an increased risk of estrogen receptor-positive (ER +) breast cancer. To characterize the metabolic shifts associated with reduced estrogen bioavailability on breast tissue, metabolomics was performed from ovary-in
Autor:
Hossein Schandiz, Maryam Lahooti, Owen Thomas, Marianne Lyngra, Joana Reis, Joao Boavida, Kjell-Inge Gjesdal, Jürgen Geisler, Jonn Terje Geitung, Torill Sauer
Publikováno v:
Breast Cancer Research and Treatment
Purpose To correlate MRI morphological response patterns with histopathological tumor regression grading system based on tumor cellularity in locally advanced breast cancer (LABC)-treated neoadjuvant with third-generation aromatase inhibitors. Method
Autor:
Mauro Maccarrone
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627273
Methods in Molecular Biology ISBN: 9781493935376
Methods in Molecular Biology ISBN: 9781493935376
Endocannabinoids (eCBs) are endogenous lipids able to activate cannabinoid receptors, the primary molecular targets of the cannabis (Cannabis sativa) active principle Δ(9)-tetrahydrocannabinol. During the last 20 years, several N-acylethanolamines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6ae9ec0092933c75abe495dbe49401
https://doi.org/10.1007/978-1-0716-2728-0_1
https://doi.org/10.1007/978-1-0716-2728-0_1
Autor:
Radosław Michalski, Jan Adamus, Karolina Dębowska, Michał Rostkowski, Renata Smulik-Izydorczyk, Adam Sikora
Publikováno v:
Cell Biochemistry and Biophysics
HNO (nitroxyl, IUPAC name azanone) is an electrophilic reactive nitrogen species of growing pharmacological and biological significance. Here, we present data on the pH-dependent kinetics of azanone reactions with the low molecular thiols glutathione
Autor:
Aiping Zheng, Nan Liu, Jing Gao, Xiaoxuan Hong, Hui Zhang, Jingru Li, Zengming Wang, Xianfu Li, Boshi Liu, Xiaolu Han, Gao Xiang
Publikováno v:
Pharmaceutical Research
Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability. Methods A bin