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Autor:
Aiping Zheng, Nan Liu, Jing Gao, Xiaoxuan Hong, Hui Zhang, Jingru Li, Zengming Wang, Xianfu Li, Boshi Liu, Xiaolu Han, Gao Xiang
Publikováno v:
Pharmaceutical Research
Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability. Methods A bin
Autor:
Kamalesh Dattaram Mumbrekar, Akheruz Zaman Ahmed, Melanie Rose D’Souza, Shakta Mani Satyam, Varun Kumar Singh, Prakashchandra Shetty
Publikováno v:
Cardiovascular Toxicology
Doxorubicin (DOX) is a potent anti-cancer antibiotic that was widely used for treatment of various cancers. It produces free radicals which result in extreme dose-limiting cardiotoxicity. This study investigated the cardioprotective potential of chia
Autor:
Susanne Johansson, Ulf Eriksson, Joanna Parkinson, Mikael Sunnåker, Jacob Leander, Sergey Aksenov, Dinko Rekić
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
Verinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for
Autor:
Masahiro Kitada, Hidetoshi Kawaguchi, Masaya Hattori, Satoshi Morita, Shinji Ohno, Yoshie Hasegawa, Toshinari Yamashita, Masahiro Kashiwaba, Kazuhiro Yanagihara, Teru Kawasoe, Norikazu Masuda, Tetsuhiro Yoshinami, Kazutaka Narui, Hiroko Bando, Nobuki Matsunami, Rikiya Nakamura, Hiroshi Yano, Masakazu Toi, Takeshi Nagashima
Publikováno v:
Investigational New Drugs
SummaryPurpose To date, it is not clear which anticancer agent is useful in combination with trastuzumab and pertuzumab As the first and second selective regimens for advanced or metastatic breast cancer (AMBC), this multicenter, open-label, phase II
Autor:
Lucyna Antkiewicz-Michaluk, Irena Nalepa, Agnieszka Wąsik, Agnieszka Zelek-Molik, Irena Romańska
Publikováno v:
Neurotoxicity Research
Parkinson's disease (PD) is a neurodegenerative disorder of the central nervous system (CNS) caused by a progressive loss of nigrostriatal dopaminergic neurons. Dysfunction of the ubiquitin-proteasome system (UPS) plays an important role in the patho
Autor:
Jasleen K Sodhi, Jason Halladay
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
The potential for new chemical entities to inhibit the major cytochrome P450 (CYP) isoforms is routinely evaluated to minimize the risk of developing drugs with drug-drug interaction liabilities. CYP inhibition assays are routinely performed in a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3717cd5ac77644b1972424de95650037
https://doi.org/10.1007/978-1-0716-1554-6_28
https://doi.org/10.1007/978-1-0716-1554-6_28
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608838
Methods in Molecular Biology ISBN: 9781493917075
Methods in Molecular Biology ISBN: 9781493917075
The discovery of opioid receptors expression on immune cells has originated a large research activity on the possible modulation by opioid drugs of immune system responses. In the present chapter we describe an easy methodology useful to obtain infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf548c6b766be09dd117e3149e49af98
https://doi.org/10.1007/978-1-0716-0884-5_18
https://doi.org/10.1007/978-1-0716-0884-5_18
Autor:
A. Turek, Bozena Kaczmarczyk, Aleksandra Borecka, Janusz Kasperczyk, Andrzej Marcinkowski, Katarzyna Stokłosa, Monika Paul-Samojedny
Publikováno v:
Pharmaceutical Research
Purpose The blood-brain barrier limits the application of idarubicin in the therapy of glioblastoma multiforme. Biodegradable, intracranial wafers with prolonged release may increase therapy efficiency. Methods Blank wafers, wafers containing 5% w/w
Publikováno v:
Methods in Molecular Biology ISBN: 9781071601624
Alzheimer's disease (AD) is an enormous healthcare challenge, and 50 million people are currently suffering from it. There are several pathophysiological mechanisms involved, but cholinesterase inhibitors remained the major target from the last 2-3 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382d2dc384f53a050b825f1513b3ef59
https://doi.org/10.1007/978-1-0716-0163-1_18
https://doi.org/10.1007/978-1-0716-0163-1_18
Autor:
Moe Wehbe, Marcel B. Bally, Nancy Dos Santos, Cody Lo, Wieslawa H. Dragowska, Armaan K. Malhotra, Malathi Anantha
Publikováno v:
Drug Delivery and Translational Research
Clioquinol (CQ) is an FDA-approved topical antifungal agent known to kill cancer cells. This facilitated the initiation of clinical trials in patients with refractory hematologic malignancies. These repurposing efforts were not successful; this was l