Zobrazeno 71 - 80
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Autor:
Wolfgang Dr Scholz, Norbert Beier
Publikováno v:
The Sodium-Hydrogen Exchanger ISBN: 9781461350712
Preclinical development of NHE subtype 1 (NHE-1) inhibitors dates back to the late 1980’s. While amiloride had been characterized as a weak and non-specific inhibitor of NHE-1, several amiloride derivatives had turned out somewhat more specific and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d40caa59c83fdbb25ed230a6126bc66b
https://doi.org/10.1007/978-1-4615-0427-6_17
https://doi.org/10.1007/978-1-4615-0427-6_17
Autor:
Garrett J. Gross
Publikováno v:
The Sodium-Hydrogen Exchanger ISBN: 9781461350712
The sodium/hydrogen antiport is the major cardiac sarcolemmal membrane transporter responsible for the control of intracellular pH under normal physiological conditions and is thought to be activated and play a major role in the control of intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdcd33a06c226461c0e76c644d18aecf
https://doi.org/10.1007/978-1-4615-0427-6_18
https://doi.org/10.1007/978-1-4615-0427-6_18
Autor:
Olga Slezakova, Wolfgang Schulze, Peter Karczewski, Ján Styk, Jan Slezak, Igor B. Buchwalow, Gerd Wallukat
Publikováno v:
Myocardial Ischemia and Preconditioning ISBN: 9781461350361
Cardiac ischaemia/reperfusion is well known as a disease of the myocytes, it is now clear that reactive oxygen species and their intermediates in conjunction with increased nitric oxide (NO) production during and after ischemia determine the second w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899e565e2923d485244f9a187a86ef59
https://doi.org/10.1007/978-1-4615-0355-2_9
https://doi.org/10.1007/978-1-4615-0355-2_9
Autor:
Verónica Sandoval, Annette E. Fleckenstein, Glen R. Hanson, J. Paul Hansen, James W. Gibb, Jeffrey M. Brown, Evan L. Riddle, Yvette V. Ugarte
Publikováno v:
Catecholamine Research ISBN: 9781441933881
The vesicular monoamine transporter-2 (VMAT-2) sequesters cytoplasmic monoamines, including dopamine (DA), into synaptic vesicles. It has been suggested that VMAT-2 is resistant to regulation by drug treatment. However, recent data indicate that agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::441362a0c6c89836148c91c7df3890b1
https://doi.org/10.1007/978-1-4757-3538-3_6
https://doi.org/10.1007/978-1-4757-3538-3_6
Autor:
Aldons J. Lusis, Diana M. Shih, Rebecca J. Richter, Clement E. Furlong, Lucio G. Costa, W.-F. Li
Publikováno v:
Paraoxonase (PON1) in Health and Disease ISBN: 9781461353584
Early studies on different human populations showed that the hydrolytic activity of serum paraoxonase (PON1) was polymorphically distributed, raising the hypothesis that individuals with low PON1 activity may be at higher risk from toxic effects due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994202c0faf1584e4f1a8a4eea21828f
https://doi.org/10.1007/978-1-4615-1027-7_8
https://doi.org/10.1007/978-1-4615-1027-7_8
Publikováno v:
Catecholamine Research ISBN: 9781441933881
(-)Deprenyl (selegiline), an inhibitor specific to type B monoamine oxidase (MAO-B), is now clinically applied for Parkinson’s disease (PD), as an adjunct of L-DOPA therapy. Recent results have shown that selegiline (Parkinson Study Group, 1989) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33104c83b2c658c353c057ed20497c5a
https://doi.org/10.1007/978-1-4757-3538-3_56
https://doi.org/10.1007/978-1-4757-3538-3_56
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461349600
Prostacyclin (PGI2), the major cyclooxygenase-derived arachidonic acid metabolite formed in macrovascular endothelial cells’, is a potent vasodilator, an inhibitor of platelet aggregation2 and smooth muscle proliferation3 in vitro and an antithromb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c622ecd9a01e66b9a64ac1213dd13ef
https://doi.org/10.1007/978-1-4615-0193-0_45
https://doi.org/10.1007/978-1-4615-0193-0_45
Publikováno v:
Flavonoids in Cell Function ISBN: 9781441933836
Dietary flavonoids have varied effects on animal cells, such as inhibition of platelet binding and aggregation, inhibition of inflammation, and anticancer properties, but the mechanisms of these effects remain largely unexplained. Adenosine receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac733a287821ddfbe572502aad3b6e0
https://doi.org/10.1007/978-1-4757-5235-9_15
https://doi.org/10.1007/978-1-4757-5235-9_15
Publikováno v:
Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171
Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthetase (1, 2) as well as of aromatic amino acid hydroxylases of phenylalanine (3), tyrosine (4), and tryptophan (5, 6). BH4-supplement has been used effectively to treat many case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a74e92800979815d9428e1b59742e0f
https://doi.org/10.1007/978-1-4615-0945-5_33
https://doi.org/10.1007/978-1-4615-0945-5_33
Autor:
M. A. Nzila
Publikováno v:
Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171
The antifolate combination of pyrimethamine (PM) and sulfadoxine (SD) [PM/SD] has increasingly become the drug of choice for the treatment of uncomplicated malaria in Africa. PM is an inhibitor of dihydrofolate reductase (DHFR), which is one componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0477a9d7a7fe65d76bb0f23959bec587
https://doi.org/10.1007/978-1-4615-0945-5_77
https://doi.org/10.1007/978-1-4615-0945-5_77