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Autor:
Gary M. Pollack, Emily O. Dumas
The opioids are commonly used to treat acute and severe pain. Long-term opioid administration eventually reaches a dose ceiling that is attributable to the rapid onset of analgesic tolerance coupled with the slow development of tolerance to the untow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccae5042a7dd95865db142f010dc294
https://europepmc.org/articles/PMC2628209/
https://europepmc.org/articles/PMC2628209/
Publikováno v:
Xenobiotics in Fish ISBN: 9781461371304
Benzocaine (ethyl para-aminobenzoate), a mammalian local anesthetic, is an effective general anesthetic agent for fish when administered by bath exposure. Its proposed use in aquaculture is to sedate fish and reduce mortality during transport and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a488c44e03ed2ddba32ba0613802ae4f
https://doi.org/10.1007/978-1-4615-4703-7_14
https://doi.org/10.1007/978-1-4615-4703-7_14
Autor:
Ryuji Ueno
Publikováno v:
Xenobiotics in Fish ISBN: 9781461371304
Sulfamonomethoxine has been efficacious in the treatment of various bacterial diseases of fish. The present paper reviews recent studies on the metabolism and pharmacokinetics of sulfamonomethoxine in edible fish species such as yellowtail, rainbow t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3fca90c41f6e8a88ca87e3805f52242
https://doi.org/10.1007/978-1-4615-4703-7_15
https://doi.org/10.1007/978-1-4615-4703-7_15
Publikováno v:
Biologic Effects of Light 1998 ISBN: 9781461372967
Vitamin metabolism and its regulation is controlled by a complex feedback loop. The biologically active metabolite calcitriol [1,25(OH)2D3] is a hormone that promotes its actions via a specific receptor (VDR) which belongs to the superfamily of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83301b1ac1f6b0ad40d375634039108c
https://doi.org/10.1007/978-1-4615-5051-8_42
https://doi.org/10.1007/978-1-4615-5051-8_42
Autor:
Toshihiro Fukushima, Takahiro Yamauchi, Hiroshi Tsutani, Sugako Matsuyama, Mikio Masada, Takanori Ueda, Toru Nakamura, Nobuyuki Gotoh, Shinji Kishi
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374565
1-β-D-arabinofuranosylcytosine (ara-C) is one of the most effective drugs for the reatment of hematologic malignancies, such as acute leukemia and malignant lym-phoma. ara-C is one of the deoxycytidine analogs. In its chemical structure OH residue i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::495a96169ae3674700a43ee0ccf64c7d
https://doi.org/10.1007/978-1-4615-5381-6_125
https://doi.org/10.1007/978-1-4615-5381-6_125
Autor:
Jacques Turgeon
Publikováno v:
Progress in Experimental Cardiology ISBN: 9781461376316
The use of orally effective angiotensin II receptor type 1 (AT1) antagonists represents a new strategy for the management of hypertension and congestive heart failure. The development of losartan, a biphenyltetrazole derivative, was based on a carefu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0fd6b969f31fd2e789d4c45bc7a77d3
https://doi.org/10.1007/978-1-4615-5743-2_13
https://doi.org/10.1007/978-1-4615-5743-2_13
Publikováno v:
Neurochemistry ISBN: 9781461374688
As is known, brain dopamine is metabolised by the enzymes monoamine oxydase and catechol-O-methyl transferase into the final metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). The very existence of two main pathways of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::072cf58ce418009622763086f5da1a85
https://doi.org/10.1007/978-1-4615-5405-9_35
https://doi.org/10.1007/978-1-4615-5405-9_35
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374305
Phenylacetate, a common metabolite of phenylalanine, is a natural component of the human plasma and an endogenous growth regulator in plants (1,2). In humans, phenylacetate conjugates glutamine to yield phenylacetylglutamine (PAG), which is subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d76ed4676d7bd8c581113cbe84f2f273
https://doi.org/10.1007/978-1-4615-5325-0_67
https://doi.org/10.1007/978-1-4615-5325-0_67
Autor:
Robert T. Dorr
Publikováno v:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2 ISBN: 9781489902207
In 1988, Dr. Brian Leyland-Jones questioned “Whither the Modulation of Platinum” in an editorial in the Journal of the National Cancer Institute (Leyland-Jones, 1988). The quest for specific chemoprotectants clearly predates the advent of platinu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19adf387a2f4d4fd2544d5acd4c083e
https://doi.org/10.1007/978-1-4899-0218-4_12
https://doi.org/10.1007/978-1-4899-0218-4_12
Autor:
Michael Soldan, Edmund Maser
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461376927
Multidrug-resistance is a major obstacle in cancer therapy with antineoplastic chemotherapeutics. Drug-resistant tumor cells frequently display overexpression of a plasma membrane phosphoglycoprotein termed P-170. P-170 is thought to act as an energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c302eeff6e73b320f0b458d5feb98f
https://doi.org/10.1007/978-1-4615-5871-2_61
https://doi.org/10.1007/978-1-4615-5871-2_61