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Autor:
Wenjiang Zhang, Michael Reedijk, Eric Chen, Hal W. Hirte, S. Percy Ivy, Ben Tran, Albiruni Ryan Abdul Razak, Brenda Cohen, Blaise Clarke, Philippe L. Bedard, Suzanne Richter, Sebastien J. Hotte, Amit M. Oza, Anastasios Stathis, Lillian L. Siu, Elaine McWhirter, Zhuo Chen, Malcolm J. Moore, Lisa Wang
Publikováno v:
Investigational New Drugs
Summary Purpose To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with gemcitabine; secondary objectives include the evaluation of safety, tolerability, pharmacokinetics, biomarkers of Notch s
Autor:
Azza A. Mahmoud, Mona Hassan Aburahma
The bioavailability of therapeutic agents from eye drops is usually limited due to corneal barrier functions and effective eye protective mechanisms. Therefore, the current study aims to enhance ocular bioavailability of brimonidine, a potent antigla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0cf005d2c6b38ac5c991e29d294fb7
https://europepmc.org/articles/PMC3225539/
https://europepmc.org/articles/PMC3225539/
Autor:
Horst Olschewski
Publikováno v:
Textbook of Pulmonary Vascular Disease ISBN: 9780387874289
Prostacyclin was the first effective therapy for patients with pulmonary arterial hypertension. The first experiences were reported in 1980 and the first patient with severe idiopathic pulmonary arterial hypertension [IPAH; formerly primary pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69f8bac67fe3d7ac2fec8e752ca2b00
https://doi.org/10.1007/978-0-387-87429-6_104
https://doi.org/10.1007/978-0-387-87429-6_104
In the present work, sustained release gastroretentive minimatrices of amoxicillin have been designed and optimized using central composite design. Effect of amount of xanthan gum, rate controlling polymers (HPMC K100M CR/PEO coagulant (1:1)), carbop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e277b66af5e2e3ad85e2c345364a0fd1
https://europepmc.org/articles/PMC2690794/
https://europepmc.org/articles/PMC2690794/
Autor:
M. Foster Olive
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461349136
Acamprosate (calcium acetylhomotaurinate) is a taurine derivative that is used as a pharmacotherapeutic for the treatment of alcoholism. In both animals and humans, acamprosate reduces alcohol intake and the propensity to relapse during abstinence. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2b38551f813878e16f97f484648f5c
https://doi.org/10.1007/978-1-4615-0077-3_57
https://doi.org/10.1007/978-1-4615-0077-3_57
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461347538
The prognosis of patients with pulmonary arterial hypertension (PAH) is poor. Available therapies (Ca++ -channel blockers, epoprostenol, bosentan) have limited efficacy or are expensive and associated with significant complications. PAH is characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99dcb91e94f4332ece631f44a1a2d789
https://doi.org/10.1007/978-1-4419-8997-0_21
https://doi.org/10.1007/978-1-4419-8997-0_21
Autor:
Olga Slezakova, Wolfgang Schulze, Peter Karczewski, Ján Styk, Jan Slezak, Igor B. Buchwalow, Gerd Wallukat
Publikováno v:
Myocardial Ischemia and Preconditioning ISBN: 9781461350361
Cardiac ischaemia/reperfusion is well known as a disease of the myocytes, it is now clear that reactive oxygen species and their intermediates in conjunction with increased nitric oxide (NO) production during and after ischemia determine the second w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899e565e2923d485244f9a187a86ef59
https://doi.org/10.1007/978-1-4615-0355-2_9
https://doi.org/10.1007/978-1-4615-0355-2_9
Autor:
Thomas G. Brock
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461349600
Eicosanoids are a diverse group of intercellular mediators derived from the enzymatic modification of arachidonic acid (AA1). The prostaglandins (PGs) and leukotrienes (LTs) are two major groups of eicosanoids. These mediators can evoke a diverse arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c0d7550827f4819495787f4622a02c
https://doi.org/10.1007/978-1-4615-0193-0_16
https://doi.org/10.1007/978-1-4615-0193-0_16
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461349600
Two, non-prostaglandin effects of antiinflammatory levels of salicylates (i.e.aspirin III) are shown here: 1) Exposure of neutrophils to aspirin or sodium salicylate inhibited Erk activity and integrin-dependent aggregation of neutrophils, consistent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cdc479b71a06072087db52ebb3a2b42
https://doi.org/10.1007/978-1-4615-0193-0_87
https://doi.org/10.1007/978-1-4615-0193-0_87
Autor:
Mario R. Romano, Charles N. Serhan, Esther Titos, Joan Clària, Nan Chiang, Gloria Pueyo, Joan Gaya
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461349600
Aspirin (acetylsalicylic acid, ASA) is the lead non-steroidal anti-inflammatory drug (NSAID) and is widely used for relieving inflammation and mild to moderate pain and fever (1, 2). In addition to its primary actions, ASA also displays a wide range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9232389adfe897013fd2a3d0901dbdd
https://doi.org/10.1007/978-1-4615-0193-0_31
https://doi.org/10.1007/978-1-4615-0193-0_31