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Autor:
Satbir Mor, Suchita Sindhu
Publikováno v:
Medicinal Chemistry Research
We report a convenient and efficient synthesis of indeno[1,2-c]pyrazol-4(1H)-ones (4a‒o) by the reaction of a variety of 2-acyl-(1H)-indene-1,3(2H)-diones (1) and 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles (2) in the p
Autor:
Orlando Antelope, Khoi Dang Le, Kuberan Balagurunathan, Yiling Bi, Anindita Roy, April Joice, Mausam Kalita, Gurusankar Ramamoorthy
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613979
Glycosaminoglycans (GAGs) play crucial roles in several biological processes including cell division, angiogenesis, anticoagulation, neurogenesis, axon guidance and growth, and viral and bacterial infections among others. The GAG cleaving hydrolases/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1672e0d730b08b474408b07f81a5a902
https://doi.org/10.1007/978-1-0716-1398-6_52
https://doi.org/10.1007/978-1-0716-1398-6_52
Autor:
Robert J. Linhardt, Li Fu
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613979
Heparin, a glycosaminoglycan-based anticoagulant drug, is prepared as an extract of animal tissues. Heparosan, an Escherichia coli (E. coli) K5 capsular polysaccharide with the structure →4)-β-D-glucuronic acid (1 → 4)-β-D-N-acetylglucosamine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47b3faefab053aeb45f08417b95db68
https://doi.org/10.1007/978-1-0716-1398-6_1
https://doi.org/10.1007/978-1-0716-1398-6_1
Autor:
Daniel O. Carmany, Ethan M. McBride, Paul S. Demond, Bernard J. Benton, Elizabeth S. Dhummakupt, Gabrielle M. Rizzo, Phillip M. Mach, Jennifer W. Sekowski, Michael W. Busch, Trevor Glaros
Publikováno v:
Journal of the American Society for Mass Spectrometry
Currently, all assays measuring acetylcholinesterase (AChE) activity following a suspected nerve agent exposure leverage methodologies that fail to identify the agent. This limits the overall effectiveness and ability to administer proper countermeas
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461348313
Salicylic acid (SA) is an effective antipyretic and analgesic agent, yet at therapeutic concentrations exerting these effects SA lacks antiinflammatory action, distinguishing it from non-steroidal antiinflammatory drugs (NSAIDs) and selective inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95b89cd2d1534dd2b78ea2cefadcfcc3
https://doi.org/10.1007/978-1-4419-9194-2_25
https://doi.org/10.1007/978-1-4419-9194-2_25
Autor:
Hideyasu Matsuda, Norikazu Matsunaga, Kyoko Takahashi, Akihiko Sumita, Kayoko Kinoshita, Junichi Azuma, Koichi Takahashi, Takahisa Matsuda
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461349136
There has recently been an increased demand for nutritional supplements and health drinks containing taurine. The Japanese diet also provides high levels of taurine. In addition, 60% of the over-the-counter (OTC) drugs classified as vitamin-mixture m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1658c7e2786d21aa6188b87f9cdfe49
https://doi.org/10.1007/978-1-4615-0077-3_30
https://doi.org/10.1007/978-1-4615-0077-3_30
Autor:
J. G. Bovill
Publikováno v:
Advances in Modelling and Clinical Application of Intravenous Anaesthesia ISBN: 9781461348306
The non-steroidal anti-inflammatory analgesics (NSAIDs) are a heterogeneous group of compounds with analgesic, anti-inflammatory and antipyretic properties. Since the experimental observations of Horton in 19631 and the subsequent work of Vane2, Smit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da7df8f2a409ef4c06bd372ace4f6983
https://doi.org/10.1007/978-1-4419-9192-8_18
https://doi.org/10.1007/978-1-4419-9192-8_18
Autor:
Makoto Murakami, Ichiro Kudo
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461348313
Prostaglandin (PG) E2, the most common prostanoid with a variety of bioactivities, has been implicated in various pathophysiologies. PGE2 is produced via three sequential enzymatic reactions: release of arachidonic acid (AA) from membrane glycerophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9882112be74a74ab5569ebb1b776e555
https://doi.org/10.1007/978-1-4419-9194-2_20
https://doi.org/10.1007/978-1-4419-9194-2_20
Autor:
Arie Ordentlich, Dana Kaplan, Baruch Velan, Avigdor Shafferman, Naomi Ariel, Dov Barak, Chanoch Kronman
Publikováno v:
Mapping the Progress of Alzheimer’s and Parkinson’s Disease ISBN: 9781475709735
Inhibitors of AChE constitute presently the only successful approach to symptomatic treatment of senile dementia of the Alzheimer’s type, with three such agents (tacrine, E2020 and rivastigmine) in clinical use1. The intensive effort to develop mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c621caecb4782bdc3e99073c04c6de00
https://doi.org/10.1007/978-0-306-47593-1_31
https://doi.org/10.1007/978-0-306-47593-1_31
Autor:
F. Mandelbaum-Shavit
Publikováno v:
Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171
Reduced folate cofactors (H4PteGlu) are essential for the biosynthesis of purines, thymidine and some amino acids, thus the antimetabolites blocking their biochemical pathways (1) have been used as effective chemotherapeutics. Methotrexate (MTX), a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e11bd920dea221dd4c2cb8d04fa5777
https://doi.org/10.1007/978-1-4615-0945-5_76
https://doi.org/10.1007/978-1-4615-0945-5_76