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Autor:
Željko Župan, Ana Jozepovic, Nenad Karanović, Dinko Tonković, Ana Borovečki, Marko Ćurković, Lovorka Brajković
Publikováno v:
Journal of Bioethical Inquiry
Volume 18
Issue 4
Volume 18
Issue 4
Healthcare professionals working in intensive care units (ICUs) are often involved in end-of-life decision-making. No research has been done so far about these processes taking place in Croatian ICUs. The aim of this study was to investigate the perc
Publikováno v:
Neuroscience Bulletin
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of
Autor:
Takayuki Yoshino, Hideaki Bando, Hiroya Taniguchi, Kei Muro, Shuichi Iino, Shigenori Kadowaki, Akihito Kawazoe, Toshiki Masuishi, Rie Kageyama
Publikováno v:
International Journal of Clinical Oncology
Background Napabucasin is an oral NAD(P)H:quinone oxidoreductase 1 bioactivatable agent that generates reactive oxygen species, is hypothesised to affect multiple oncogenic cellular pathways, including STAT-3, and is expected to result in cancer cell
Publikováno v:
Neuroscience Bulletin
Steroid hormones play important roles in brain development and function. The signaling of steroid hormones depends on the interaction between steroid receptors and their coactivators. Although the function of steroid receptor coactivators has been ex
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling
Autor:
Cong Chen, Wen Yin, Min Luo, Yan Wang, Ling-Xiang Wu, Hai-Tao Guo, Yi-Fang Ping, Chun-Hua Luo, Wei Chen, Yu-Qi Liu, Lin-Rong Che, Zhong-yi Qin, Tian-Ran Li, Qianghu Wang, Shuang Wang, Chao Wang, Kaidi Yang, Zhi-Cheng He, Sheng-Qing Lv, Wen-Ying Wang, Hua Feng, Bin Wang, Xiao-Ning Zhang, Min Mao, Yu Shi, Yaoyao Tan, Qing-Rui Li, Xiu-Wu Bian, Qing Liu
Publikováno v:
Cell Research
Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in mediating chemoresi
Publikováno v:
World Journal of Pediatrics
World journal of pediatrics : WJP, vol 17, iss 4
World journal of pediatrics : WJP, vol 17, iss 4
Background We aimed to evaluate the effects of interfacility pediatric critical care transport response time, physician presence during transport, and mode of transport on mortality and length of stay (LOS) among pediatric patients. We hypothesized t
Autor:
Kyoko Koshibu, Jorge Hurtado de Mendoza, Ainhoa Alzualde, Diogo A. R. S. Latino, Manuel C. Peitsch, Julia Hoeng, Oihane Jaka, Omar Alijevic, Pavel Pospisil, Iñaki Iturria, Stefan Frentzel
Publikováno v:
Journal of Natural Medicines
Alkaloids are a structurally complex group of natural products that have a diverse range of biological activities and significant therapeutic applications. In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine recep
Publikováno v:
Clinical and Experimental Nephrology
Background Tolvaptan is a vasopressin type 2 receptor antagonist and has been used to treat autosomal dominant polycystic kidney disease (ADPKD) since 2014. There has been limited real-world data on the safety and efficacy of tolvaptan. Methods This
Autor:
Shuang-Qu Li, Xi Cheng, Yi Wang, Zhaobing Gao, Xu-Rui Shen, Yan Wu, Sui Fang, Weijuan Shang, Bingqing Xia, Jian-Rong Xu, Leike Zhang
Publikováno v:
Acta Pharmacologica Sinica
Lack of efficiency has been a major problem shared by all currently developed anti-SARS-CoV-2 therapies. Our previous study shows that SARS-CoV-2 structural envelope (2-E) protein forms a type of cation channel, and heterogeneously expression of 2-E
Autor:
Pu Gao, Chaoyang Meng, Hua Peng, Yifan Lin, Yang Pu, Fang Zhao, Yang Xin Fu, Yueqi Cai, Haibin Huang, Tian-Zhang Song, Yu Gao, Zhenxiang Hu, Silin Zhang, Jing Sun, Hairong Xu, Yalan Zhu, Lin Cheng, Dan-Dan Yu, Yong-Tang Zheng, Jian-Bao Han, Shiyu Sun, Xiao-Li Feng, Zheng Zhang, Haidong Tang, Jincun Zhao, Jiaming Yang
Publikováno v:
Cell Research
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global crisis, urgently necessitating the development of safe, efficacious, convenient-to-store, and low-cost vaccine options. A major challenge is that the receptor-binding do