Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Molecular and Cellular Biochemistry. 270:89-97
Tumor microenvironment, which is characterized by hypoxia, low-glucose concentrations, high-lactate concentrations, low-extracellular pH, can alter the therapeutic response in tumors. In this study, we investigated whether hypoxia affects TRAIL-induc
Autor:
Ki M. Kim, Yong J. Lee
Publikováno v:
Oncogene. 24:355-366
We have previously shown that low extracellular pH (pHe) promotes cell killing by the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In this study, we examined whether amiloride, an inhibitor of the Na(+)/H(+) antiporter capable of
Autor:
Shivendra V. Singh, Victor G. Vogel, Sunga Choi, Dong Xiao, Yong J. Lee, Daniel Johnson, Candace S. Johnson, Donald L. Trump
Publikováno v:
Oncogene. 23:5594-5606
Garlic-derived organosulfides (OSCs) including diallyl trisulfide (DATS) are highly effective in affording protection against chemically induced cancer in animals. Evidence is also mounting to indicate that some naturally occurring OSCs can suppress
Publikováno v:
Cell Death & Differentiation. 9:448-456
We previously reported that overexpression of HSP25 delayed cell growth, increased the level of p21(waf), reduced the levels of cyclin D1, cyclin A and cdc2, and induced radioresistance in L929 cells. In this study, we demonstrated that HSP25 induced
Publikováno v:
Cancer Gene Therapy. 8:397-404
Tumor cells that express a fusion gene of Escherichia coli cytosine deaminase (CD) and herpes simplex virus type 1 thymidine kinase (TK) sequences activate and are subsequently killed by the nontoxic prodrugs 5-fluorocytosine and ganciclovir. We have
Autor:
Jessup Jm, Kyung-Hwa Lee, Song Yk, Timothy R. Billiar, Kim Hr, Dai-Wu Seol, Yong J. Lee, Kim Th
Publikováno v:
Oncogene. 20:1476-1485
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL, Apo-2L) is a recently characterized member of the family of programmed cell death-inducing ligands that includes TNF-alpha and CD95L (FasL). It is well known that TRAIL binds to the
Publikováno v:
Cell Death & Differentiation. 8:44-50
Cyclin D1 expression is co-regulated by growth factor and cell adhesion signaling. Cell adhesion to the extracellular matrix activates focal adhesion kinase (FAK), which is essential for cyclin D1 expression. Upon the loss of cell adhesion, cyclin D1
Autor:
Yong J. Lee, Peter M. Corry
Publikováno v:
Molecular and Cellular Biochemistry. 202:1-8
Although the synthesis of angiogenic factors in hypoxic regions of solid tumors is recognized as one of the critical steps in tumor growth and metastasis, the signal transduction pathway involved in hypoxic induction of basic fibroblast growth factor
Autor:
Christine M. Berns, Peter M. Corry, Sandra Galoforo, Roman Klemenz, Robert V. Blackburn, Yong J. Lee
Publikováno v:
Molecular and Cellular Biochemistry. 170:31-42
We have previously shown that murine L929 cells do not express the small heat shock protein αB-crystallin upon exposure to thermal stress (Mol Cell Biochem 155: 51–60, 1996). In these studies, we demonstrate that L929 cells also fail to express α
Autor:
Kun-Liang Guan, Sandra Galoforo, Christine M. Berns, Alvaro Martinez, Peter M. Corry, Yong J. Lee, Xiao-yu Wu, Anjali K. Gupta
Publikováno v:
Molecular and Cellular Biochemistry. 170:23-30
We have investigated the effect of glucose deprivation treatment on the activation of mitogen activated protein kinases (MAPKs) in the drug-sensitive human breast carcinoma cells (MCF-7) and its drug resistant variant (MCF-7/ADR) cells. Western blots