Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tarjinder Singh"'
Autor:
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Nature Aging. 2:837-850
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependen
Autor:
Cheryl A. Roe, Claire Churchhouse, Wei J. Chen, Felecia Cerrato, Sharon D. Chandler, Menachem Fromer, Ashley Dumont, Stephen V. Faraone, Stephen J. Glatt, Benjamin M. Neale, Hai-Gwo Hwu, Giulio Genovese, Mark J. Daly, Nan M. Laird, Samuel A. Rose, Shi-Heng Wang, Kaitlin E. Samocha, Kimberly Chambert, Jennifer L. Moran, Daniel P. Howrigan, Jack A. Kosmicki, Tarjinder Singh, Steven A. McCarroll, Ming T. Tsuang
Publikováno v:
Nature neuroscience, vol 23, iss 2
Nature neuroscience
Nature neuroscience
Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far been shown to be modest. We analyzed DNMs from 1,695 SCZ-affected trios and
Autor:
Francesco Lescai, Duncan S. Palmer, Ditte Demontis, Merete Nordentoft, Ole Mors, Marie Bækvad-Hansen, Satterstrom Fk, Elise B. Robinson, Anders D. Børglum, Julian Maller, Jack A. Kosmicki, Raymond K. Walters, David M. Hougaard, Tarjinder Singh, Emilie M. Wigdor, Christine Stevens, Mark J. Daly, Bo Mortensen P, Jakob Grove, Benjamin M. Neale, Thomas Werge, Jonas Bybjerg-Grauholm
Publikováno v:
Satterstrom, F K, Walters, R K, Singh, T, Wigdor, E M, Lescai, F, Demontis, D, Kosmicki, J A, Grove, J, Stevens, C, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Palmer, D S, Maller, J B, iPSYCH-Broad Consortium, Nordentoft, M, Mors, O, Robinson, E B, Hougaard, D M, Werge, T M, Bo Mortensen, P, Neale, B M, Børglum, A D & Daly, M J 2019, ' Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants ', Nature Neuroscience, vol. 22, no. 12, pp. 1961-1965 . https://doi.org/10.1038/s41593-019-0527-8
Nature neuroscience
Nature neuroscience
The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar
Autor:
Katherine Lachlan, Elena Prigmore, Emma Clement, Patrick J. Short, Katrina Prescott, David R. FitzPatrick, Petr Danecek, Kate Chandler, Holly Ironfield, Alejandro Sifrim, Helen V. Firth, Giuseppe Gallone, Matthew E. Hurles, Tarjinder Singh, Eugene J. Gardner, Sebastian S. Gerety, Kaitlin E. Samocha, Juliet Handsaker, Elisabeth Rosser
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Mobile genetic Elements (MEs) are segments of DNA which can copy themselves and other transcribed sequences through the process of retrotransposition (RT). In humans several disorders have been attributed to RT, but the role of RT in severe developme
Autor:
Harvest Mariki, Stephan Menzel, Julie Makani, Jeffrey C. Barrett, Bruno Mmbando, Tarjinder Singh, Deogratius Soka, Helen Rooks, Sharon E. Cox, Josephine Mgaya, Siana Nkya Mtatiro, Swee Lay Thein
Publikováno v:
BMC Medical Genetics
BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individu