Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Serge Y. Fuchs"'
Autor:
Hongru Zhang, Pengfei Yu, Vivek S. Tomar, Xiangjie Chen, Matthew J. Atherton, Zhen Lu, Hong-Guang Zhang, Shifeng Li, Angelica Ortiz, Jun Gui, N. Adrian Leu, Fangxue Yan, Andres Blanco, Mirella L. Meyer-Ficca, Ralph G. Meyer, Daniel P. Beiting, Jinyang Li, Selene Nunez-Cruz, Roddy S. O’Connor, Lexus R. Johnson, Andy J. Minn, Subin S. George, Constantinos Koumenis, J. Alan Diehl, Michael C. Milone, Hui Zheng, Serge Y. Fuchs
Publikováno v:
Nature Cancer. 3:808-820
Evasion of antitumor immunity and resistance to therapies in solid tumors are aided by an immunosuppressive tumor microenvironment (TME). We found that TME factors, such as regulatory T cells and adenosine, downregulated type I interferon receptor IF
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications. 13
Heterogeneous Nuclear Ribonucleoprotein K (hnRNPK) is a multifunctional RNA binding protein (RBP) localized in the nucleus and the cytoplasm. Abnormal cytoplasmic enrichment observed in solid tumors often correlates with poor clinical outcome. The me
Autor:
Jun Gui, Angelica Ortiz, Cindy Sander, Leslie Todd, J. Alan Diehl, Sandra Ryeom, Dmitry I. Gabrilovich, Christina Cho, John M. Kirkwood, Kevin Alicea-Torres, Jinyang Li, Andrew Wakeham, Kanstantsin V. Katlinski, Bryan E. Snow, Ben Z. Stanger, Daniel P. Beiting, Hongru Zhang, Farima Zahedi, Serge Y. Fuchs, Tak W. Mak, Ellen Puré, Constantinos Koumenis
Publikováno v:
Nature Cancer. 1:603-619
Primary tumor-derived factors act upon normal cells to generate a pre-metastatic niche, which promotes colonization of target organs by disseminated malignant cells. Here we report that tumor-derived factor-induced activation of the p38α kinase in l
Autor:
Hemma Murali, Ajeya Nandi, Serge Y. Fuchs, Ratnesh Kumar Srivastava, Sabrina Kim, M. Raza Zaidi, Snahlata Singh, Mario Andres Blanco, Sushil Kumar, Rizwan Saffie, Gatha Thacker, Luca Busino, Mary Baldeon, Rumela Chakrabarti, Satrajit Sinha, John W. Tobias
Publikováno v:
Nat Cell Biol
Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that loss of the tumour suppressive transcription factor Elf5 in TNBC ce
Autor:
Kevin Alicea-Torres, Agnieszka Rynda-Apple, Andrew V. Kossenkov, Jinyun Chen, Shuyu Fu, Emilio Sanseviero, Brian Nam, Qiujin Yu, Dmitry I. Gabrilovich, Serge Y. Fuchs, Fred Denstman, Jun Gui, Gregory A. Masters, Filippo Veglia, Laxminarasimha Donthireddy, Neil Hockstein, Cindy Lin, Charles Mulligan, Joseph R. Bennett, Yulia Nefedova
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils and monocytes with potent immune suppressive activity. These cells play an important role in accelerating tumor progression and undermining the efficacy of anti-cancer t
Autor:
Frank Chinga, Serge Y. Fuchs, Zoya Ignatova, Jiangbin Ye, Crystal S. Conn, Weixuan Fu, Constantinos Koumenis, Andrew V. Kossenkov, Carlo Salas Salinas, Ioannis I. Verginadis, Nektaria Maria Leli, Ravi K. Amaravadi, Christine Polte, Paul P. Wang, Alexandra M Monroy, Davide Ruggero, J. Alan Diehl, Feven Tameire, Rani Ojha
Publikováno v:
Nature cell biology, vol 21, iss 7
Nature cell biology
Nature cell biology
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. Here we reveal an essential role
Autor:
Nilesh Chitnis, Kent Armeson, Constantinos Koumenis, Gerald Wertheim, Yiwen Bu, J. Alan Diehl, Akihiro Yoshida, Chi V. Dang, Amanda R. Oran, Feven Tameire, Davide Ruggero, Serge Y. Fuchs, Victoria J. Gennaro, Brian J. Altman, Steven B. McMahon
Publikováno v:
Nature Cell Biology. 20:104-115
The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR sig
Autor:
Luca Busino, Sushil Kumar, Mario Andres Blanco, Hemma Murali, Satrajit Sinha, Rizwan Saffie, John W. Tobias, M. Raza Zaidi, Rumela Chakrabarti, Serge Y. Fuchs, Ajeya Nandi, Gatha Thacker, Mary Baldeon, Ratnesh Kumar Srivastava, Sabrina Kim, Snahlata Singh
Publikováno v:
Nature Cell Biology. 23:1048-1048
Autor:
Nektaria Maria Leli, Frank Chinga, Christine Polte, Paul P. Wang, Davide Ruggero, Feven Tameire, Ioannis I. Verginadis, Alexandra M Monroy, Constantinos Koumenis, Crystal S. Conn, Weixuan Fu, Rani Ojha, J. Alan Diehl, Zoya Ignatova, Andrew V. Kossenkov, Serge Y. Fuchs, Jiangbin Ye, Ravi K. Amaravadi, Carlo Salas Salinas
Publikováno v:
Nature Cell Biology. 21:1052-1052
Autor:
Boun L Thai, Serge Y. Fuchs, Yuval Shaked, Jane Lee, Yaacov Ben-David, Robert S. Kerbel, Brian J Pak, Ze'ev Ronai
Publikováno v:
Oncogene. 23:30-38
While melanomas are resistant to the cytotoxic effects of radiotherapy, little is known about the molecular mechanisms underlying this intrinsic resistance. Here, we describe the utilization of retroviral insertional mutagenesis to facilitate the ana