Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Roy H. Perlis"'
Publikováno v:
Molecular Psychiatry. 27:3898-3903
Autor:
Thomas, Parmentier, Fiona M K, James, Elizabeth, Hewitson, Craig, Bailey, Nicholas, Werry, Steven D, Sheridan, Roy H, Perlis, Melissa L, Perreault, Luis, Gaitero, Jasmin, Lalonde, Jonathan, LaMarre
Publikováno v:
Scientific Reports. 12
Activity-induced neurogenesis has been extensively studied in rodents but the lack of ante mortem accessibility to human brain at the cellular and molecular levels limits studies of the process in humans. Using cerebral spheroids derived from human i
Publikováno v:
Journal of Perinatology. 41:2590-2596
We sought to develop a prediction model using prenatal diagnosis codes that could help clinicians objectively stratify a women’s risk for delivery-related morbidity. We performed a prospective cohort study of women delivering at a single academic m
Autor:
Roy H. Perlis, W. Michael Vanderlind, George S. Alexopoulos, Chaya B Fridman, Abhishek Jaywant, Faith M. Gunning
Publikováno v:
Neuropsychopharmacology
BackgroundCognitive impairment is common following critical illness. A number of case reports and case series have suggested that cognitive deficits occur in patients with COVID-19. This study evaluated the frequency, severity, and profile of cogniti
Autor:
Ronna Fried, Joseph Biederman, Maura DiSalvo, Elizabeth Noyes, Haley Driscoll, Stephen V. Faraone, K. Yvonne Woodworth, Itai Biederman, Roy H. Perlis
Publikováno v:
Psychopharmacology. 237:2835-2843
ADHD is a prevalent and morbid neurobiological disorder affecting up to 5% of adults. While stimulants have been documented to be safe and effective in adults with ADHD, uncertainties remain about adherence to these treatments. The main aim of this a
Autor:
Till F. M. Andlauer, Glyn Lewis, Brenda W.J.H. Penninx, Toni-Kim Clarke, Douglas F. Levinson, Alexander Viktorin, Kenneth S. Kendler, Yuri Milaneschi, Giorgio Pistis, Nicholas G. Martin, Jordan W. Smoller, Bertram Müller-Myhsok, Mark Adams, Myrna M. Weissman, Andreas J. Forstner, Enda M. Byrne, Hans J. Grabe, Roy H. Perlis, Ole Mors, James B. Potash, Jonathan Flint, Steven P. Hamilton, Jianxin Shi, Rudolf Uher, Joana A. Revez, Sandra Van der Auwera, Fabien Streit, Na Cai, Gerome Breen, Cathryn M. Lewis, Henning Tiemeier, Martin Preisig
Publikováno v:
Nat. Genet. 52, 437-447 (2020)
Nature Genetics, 52(4), 437-447. Nature Publishing Group
Nat Genet
Cai, N, Revez, J A, Flint, J & MDD Working Group of the Psychiatric Genomics Consortium 2020, ' Minimal phenotyping yields genome-wide association signals of low specificity for major depression ', Nature Genetics, vol. 52, no. 4, pp. 437-447 . https://doi.org/10.1038/s41588-020-0594-5
NATURE GENETICS
Cai, N, Revez, J A, Adams, M J, Andlauer, T F M, Breen, G, Byrne, E M, Clarke, T, Forstner, A J, Grabe, H J, Hamilton, S P, Levinson, D F, Lewis, C M, Lewis, G, Martin, N G, Milaneschi, Y, Mors, O, Müller-myhsok, B, Penninx, B W J H, Perlis, R H, Pistis, G, Potash, J B, Preisig, M, Shi, J, Smoller, J W, Streit, F, Tiemeier, H, Uher, R, Van Der Auwera, S, Viktorin, A, Weissman, M M, Kendler, K S & Flint, J 2020, ' Minimal phenotyping yields genome-wide association signals of low specificity for major depression ', Nature Genetics, vol. 52, no. 4, pp. 437-447 . https://doi.org/10.1038/s41588-020-0594-5
MDD Working Group of the Psychiatric Genomics Consortium 2020, ' Minimal phenotyping yields genome-wide association signals of low specificity for major depression ', Nature Genetics, vol. 52, no. 4, pp. 437-447 . https://doi.org/10.1038/s41588-020-0594-5
Nature Genetics, 52(4), 437-447. Nature Publishing Group
Nat Genet
Cai, N, Revez, J A, Flint, J & MDD Working Group of the Psychiatric Genomics Consortium 2020, ' Minimal phenotyping yields genome-wide association signals of low specificity for major depression ', Nature Genetics, vol. 52, no. 4, pp. 437-447 . https://doi.org/10.1038/s41588-020-0594-5
NATURE GENETICS
Cai, N, Revez, J A, Adams, M J, Andlauer, T F M, Breen, G, Byrne, E M, Clarke, T, Forstner, A J, Grabe, H J, Hamilton, S P, Levinson, D F, Lewis, C M, Lewis, G, Martin, N G, Milaneschi, Y, Mors, O, Müller-myhsok, B, Penninx, B W J H, Perlis, R H, Pistis, G, Potash, J B, Preisig, M, Shi, J, Smoller, J W, Streit, F, Tiemeier, H, Uher, R, Van Der Auwera, S, Viktorin, A, Weissman, M M, Kendler, K S & Flint, J 2020, ' Minimal phenotyping yields genome-wide association signals of low specificity for major depression ', Nature Genetics, vol. 52, no. 4, pp. 437-447 . https://doi.org/10.1038/s41588-020-0594-5
MDD Working Group of the Psychiatric Genomics Consortium 2020, ' Minimal phenotyping yields genome-wide association signals of low specificity for major depression ', Nature Genetics, vol. 52, no. 4, pp. 437-447 . https://doi.org/10.1038/s41588-020-0594-5
Minimal phenotyping refers to the reliance on the use of a small number of self-reported items for disease case identification, increasingly used in genome-wide association studies (GWAS). Here we report differences in genetic architecture between de
Autor:
Brian A. Rodriguez, Jason P. Weick, Michela Dell'Orco, Jasmin Lalonde, Nikolaos Mellios, Alexander Hafez, Begum Alural, Jonathan L. Brigman, Nora I. Perrone-Bizzozero, Brigham J. Hartley, Praveen Chander, Evelyn Lozano, Kristen J. Brennand, Amber Zimmerman, Stephen J. Haggarty, Maree J. Webster, Roy H. Perlis, Stephen K. Amoah
Publikováno v:
Molecular Psychiatry
Although circular RNAs (circRNAs) are enriched in the mammalian brain, very little is known about their potential involvement in brain function and psychiatric disease. Here, we show that circHomer1a, a neuronal-enriched circRNA abundantly expressed
Autor:
Carl M. Sellgren, Joy E. Horng, Andrea G. Edlow, Steven D. Sheridan, Liam T. McCrea, Roy H. Perlis, Rose M. De Guzman, Ting Fu, Jessica M. Thanos
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potentia
Autor:
Jessica M. Thanos, Jessica Gracias, Carl M. Sellgren, Roy H. Perlis, Ajamete Kaykas, Rakesh Karmacharya, Kathleen A. Worringer, Paul B. Whittredge, Carleton Goold, Steven D. Sheridan, Jonathan D. Biag, Hannah E. Brown, Bradley Watmuff, Ting Fu, Jennifer P. Wang
Publikováno v:
Nature Neuroscience. 22:374-385
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse
Autor:
Roy H. Perlis, Hualin Simon Xi, Leonard M. Eisenberg, Sangmi Chung, Alexander A. Moghadam, Donna L. McPhie, Bruce M. Cohen, Weihua Huang, Woong Bin Kim, Patric K. Stanton, Changhong Yin, Sarah E. Cote, Teruyoshi Hirayama, Joyce Zhao, Judith L. Rapoport, Emi Fukuda, Takeshi Yagi, Kevin Eggan, Elizabeth Noyes, Sulagna Ghosh, Dost Öngür, James M. Park, Daniel R. Weinberger, Teagan Parsons, Kelvin Zheng, Joshua J. Park, Thomas A. Lanz, Karen F. Berman, Jun-Hyeong Cho, Christine T. O. Nguyen, Haneul Noh, Hae Young Kim, Joseph T. Coyle, Jose A. Apud, Peiyan Ni, Richard E. Straub, Zhicheng Shao
Publikováno v:
Nature Neuroscience. 22:229-242
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received function