Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Philippa C, Matthews"'
Autor:
Duncan Cook, Philippa C Matthews, Jeremy Farrar, Derrick W. Crook, David W Eyre, Tim E. A. Peto, Emma Rourke, John I. Bell, Karina Doris Vihta, Thomas House, Ruth Studley, Koen B. Pouwels, Emma Pritchard, A. Sarah Walker, Nicole Stoesser, John N Newton, Ian Diamond, Jodie Hay
Publikováno v:
Nature Medicine
The effectiveness of the BNT162b2 and ChAdOx1 vaccines against new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections requires continuous re-evaluation, given the increasingly dominant B.1.617.2 (Delta) variant. In this study, we
Autor:
John I. Bell, Thomas House, Emma Rourke, Harper VanSteenHouse, Joel Jones, A. Sarah Walker, Ruth Studley, Nicole Stoesser, Philippa C Matthews, John N Newton, Jeremy Farrar, Ian Diamond, Tim E. A. Peto, Koen B. Pouwels, David W Eyre, I Bell, Emma Pritchard, Derrick W. Crook, Owen Gethings, Karina Doris Vihta
Publikováno v:
Nature Medicine
The effectiveness of COVID-19 vaccination in preventing new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the general community is still unclear. Here, we used the Office for National Statistics COVID-19 Infection Survey
Autor:
Timothy M Walker, Daniel Ebner, Philippa C Matthews, David I. Stuart, Stephanie B Hatch, Denise O'Donnell, Brian D. Marsden, Katie Jeffery, Alison Howarth, Gavin R. Screaton, D W Crook, Nicole Stoesser, Tim James, Peto Tea., David W Eyre, Christopher P. Conlon, Sheila F Lumley, Stuart Cox, Richard J. Cornall
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Infectious Diseases
BMC Infectious Diseases
Background Thresholds for SARS-CoV-2 antibody assays have typically been determined using samples from symptomatic, often hospitalised, patients. In this setting the sensitivity and specificity of the best performing assays can both exceed 98%. Howev
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 18:146-147
Progress towards hepatitis B virus (HBV) elimination targets remains slow, despite efforts to support enhanced prevention, diagnosis and treatment. On the basis of insights from interventions against HIV, we argue for the wider use of antiviral thera
Autor:
Paul Kellam, Philippa C Matthews, Todd M. Allen, Astrid Gall, Reena R. D’Souza, Jacqui Brener, Oliver G. Pybus, Nora Lavandier, Fabian Chen, Anne Edwards, Rebecca Batorsky, Jacob Hurst, Chrissy Bolton, Philip J. R. Goulder
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018)
Retrovirology
Retrovirology
Background The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-
Autor:
Philippa C Matthews, Paul Kellam, Rebecca Batorsky, Philip J. R. Goulder, Todd M. Allen, Søren Buus, Astrid Gall, Ellen M. Leitman, Jacqui Brener, Lynn Riddell
Publikováno v:
Europe PubMed Central
Retrovirology
Retrovirology
Background The precise immune responses mediated by HLA class I molecules such as HLA-B*27:05 and HLA-B*57:01 that protect against HIV disease progression remain unclear. We studied a CRF01_AE clade HIV infected donor-recipient transmission pair in w
Autor:
Anna Maria Geretti, Philip J. R. Goulder, Paul Klenerman, Thumbi Ndung'u, Apostolos Beloukas, Amna Malik, Philippa C Matthews
Publikováno v:
BMC Infectious Diseases
Anti-Retroviral Therapy (ART) has dramatically reduced morbidity and mortality associated with HIV/AIDS. However, this has left a niche for the emergence of liver disease in HIV-positive individuals co-infected with HBV. Despite the geographical over
Autor:
Philip J. R. Goulder, William H. Hildebrand, P Chatkulkawin, U Hempel, Bruce D. Walker, Philippa C Matthews, Todd M. Allen, Patrawadee Pitakpolrat, Thomas Leitner, Rachel L. Allgaier, S Lorenzen, LC Phillips, Supranee Buranapraditkun, Kiat Ruxrungtham
Publikováno v:
Retrovirology, Vol 6, Iss Suppl 3, p P236 (2009)
Retrovirology
Europe PubMed Central
Retrovirology
Europe PubMed Central
Methods We studied a cohort of 250 chronically HIV-1 infected, HAART naive individuals in Bangkok, Thailand. Viral load and CD4 data were collected for all individuals as well as 4-digit HLA typing and viral sequences. A comprehensive screen of CD8+
Autor:
Philippa C Matthews, R. B. Stein
Publikováno v:
Nature. 208:1217-1218
THE frequency of action potentials in a nerve fibre has long been known to be a function of the input intensity. Fluctuations in frequency when the stimulus is held constant have often been considered merely as unwanted ‘noise’ limiting the accur