Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nicholas M. Boulis"'
Publikováno v:
Neurosurgical Review. 43:1039-1046
Malignant peripheral nerve sheath tumors (MPNST) are a rare and aggressive group of tumors that are challenging to treat. Neurofibromatosis type 1 (NF-1)-associated MPNSTs have been associated with poorer clinical outcomes. The treatment options for
Autor:
Purva Nagarajan, Raphael James, John N. Oshinski, Thais Federici, Nicholas M. Boulis, Andrey Krasnopeyev, Cristin Roach, Pavlos Texakalidis, Stewart G. Neill, Jeffrey N. Bruce, Peter Canoll, Muhibullah S Tora, Jeremy Wetzel, Rima S. Rindler, Nathan Hardcastle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Background: Prior studies have applied driver mutations targeting the RTK/RAS/PI3K and p53 pathways to induce the formation of high-grade gliomas in rodent models. In the present study, we report the production of a high-grade spinal cord glioma mode
Publikováno v:
Ann Biomed Eng
The neurodegenerative disease amyotrophic lateral sclerosis (ALS) results in the death of motor neurons in voluntary muscles. There are no cures for ALS and few available treatments. In studies with small animal models, injection of cellular therapeu
Autor:
David J. Fink, John H. Wolfe, Joseph C. Glorioso, Maria G. Castro, Michele Simonato, Pedro R. Lowenstein, Nicholas M. Boulis, Steven J. Gray, Luk H. Vandenberghe, William F. Goins, Thomas J. Wilson, Jean Bennett
Publikováno v:
Nature Reviews Neurology. 9:277-291
Diseases of the nervous system have devastating effects and are widely distributed among the population, being especially prevalent in the elderly. These diseases are often caused by inherited genetic mutations that result in abnormal nervous system
Autor:
Stacey A. Sakowski, Jonathan D. Glass, Nicholas M. Boulis, J. Simon Lunn, Eva L. Feldman, Thais Federici
Publikováno v:
Nature Reviews Neurology. 8:172-176
Effective treatments are urgently needed for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the loss of motor neurons. In 2009, the FDA approved the first phase I safety trial of direct intraspinal transplanta
Autor:
Steven J. Gray, Richard Jude Samulski, Marco A. Passini, K A Matthews, Chalonda R. Handy, Thais Federici, Jason Taub, Joshua C Grieger, Griffin R. Baum, Nicholas M. Boulis
Publikováno v:
Gene Therapy. 19:852-859
Adeno-associated viral vector 9 (AAV9) has recently been shown to penetrate the blood–brain barrier via intravascular administration, making it a good candidate for diffuse gene delivery. However, the potential side effects of systemic delivery are
Autor:
Jonathon Riley, Nicholas M. Boulis, Qingshan Teng, Erin Carlton, Shearwood McClelland, Thais Federici, Jun Yang, Mary E. Garrity-Moses
Publikováno v:
NeuroMolecular Medicine. 9:276-284
Clostridial light chain (LC) inhibits synaptic transmission by digesting a vesicle-docking protein, syna- ptobrevin, without killing neurons. We here report the fea- sibility of creating a rat hemiparkinsonism model through LC gene expression in the
Publikováno v:
Pituitary. 3:185-188
The cyclic somatostatin analog, octreotide, forms the mainstay of medical treatment for acromegaly. In addition to lowering circulating growth hormone levels and shrinking tumor size, octreotide may provide symptomatic relief of headaches associated
Autor:
Douglas Kondziolka, Fred G. Barker, Michael A. Vogelbaum, Anthony L. Asher, Nicholas M. Boulis, Nathan R. Selden, Brian L. Hoh
Publikováno v:
Journal of Neuro-Oncology. 93
Introduction Cerebral metastases are a common problem and pose complex treatment decisions, with reference to local control of treated lesions, prevention of new brain metastases, and toxicity of available treatments. At the 2007 Congress of Neurolog
Autor:
Joseph C. Glorioso, Maria G. Castro, John H. Wolfe, Luk H. Vandenberghe, David Fink, Nicholas M. Boulis, William F. Goins, Thomas J. Wilson, Michele Simonato, Pedro R. Lowenstein, Jean Bennett, Steven J. Gray
Publikováno v:
Nature Reviews Neurology. 9:298-298
Nat. Rev. Neurol. 9, 277–291 (2013); doi:10.1038/nrneurol.2013.56 In the version of this article initially published, HSV-1‒thymidine kinase was incorrectly referred to as tyrosine kinase in Table 4, and as HSV1‒tyrosine kinase on page 288. The