Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mitsuhiko Ikura"'
Autor:
Teklab Gebregiworgis, Christopher B. Marshall, Fenneke KleinJan, Geneviève M.C. Gasmi-Seabrook, Ben J Eves, Masahiro Enomoto, Ningdi F Liu, Ki-Young Lee, Mitsuhiko Ikura, Zhenhao Fang
Publikováno v:
Journal of Biomolecular NMR. 74:531-554
Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase domain and a C-terminal lipid-modified tail that is unique to each isoform. The GTPase domain is
Publikováno v:
Nature Chemical Biology. 18:578-579
Autor:
Shigenobu Yonemura, Noboru Ishiyama, Anna B. Kobb, Rodrigo Fernandez-Gonzalez, Ulrich Tepass, Mitsuhiko Ikura, Annette S. Flozak, Deborah E. Leckband, Samantha K. Barrick, Alexander Yemelyanov, Megan N. Wood, Tadateru Nishikawa, Ritu Sarpal, Cara J. Gottardi, Hanako Hayashi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
α-catenin is a key mechanosensor that forms force-dependent interactions with F-actin, thereby coupling the cadherin-catenin complex to the actin cytoskeleton at adherens junctions (AJs). However, the molecular mechanisms by which α-catenin engages
Autor:
Sam Seymour, Paul Meraner, Aparna Gudlur, Prasanna Srinivasan, Peter B. Stathopulos, Mitsuhiko Ikura, Patrick G. Hogan, Yubin Zhou, Anjana Rao, Shiva Razavi
Publikováno v:
Nature structural & molecular biology
Physiological Ca2+ signalling in T lymphocytes and other cells depends on the STIM-ORAI pathway of store-operated Ca2+ entry. STIM1 and STIM2 are Ca2+ sensors located in the endoplasmic reticulum (ER) membrane, with ER-luminal domains that monitor ce
Publikováno v:
Nature Cell Biology. 15:261-273
The linkage of adherens junctions to the actin cytoskeleton is essential for cell adhesion. The contribution of the cadherin-catenin complex to the interaction between actin and the adherens junction remains an intensely investigated subject that cen
Publikováno v:
Cellular and Molecular Life Sciences. 70:3989-4008
In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding transcription factors that recognize promoter and enhancer elements near the transcriptional start site. Some coactivators promote transcription by connecting trans
Autor:
Tapas K. Mal, Hideaki Mizuno, Mitsuhiko Ikura, Takashi Fukano, Atsushi Miyawaki, Markus Wälchli
Publikováno v:
Journal of Biomolecular NMR. 48:237-246
Dronpa is a green fluorescent protein homologue with a photochromic property. A green laser illumination reversibly converts Dronpa from a green-emissive bright state to a non-emissive dark state, and ultraviolet illumination converts it to the brigh
Autor:
Thomas Acton, Tapas K. Mal, Mitsuhiko Ikura, G. V. T. Swapna, Ahmad Khorchid, Masanori Takayama, Haiping Ke, Sangita Phadtare, Bing Xia, Gaetano T. Montelione, Guoliang Qing, Li Chung Ma, Masayori Inouye
Publikováno v:
Nature Biotechnology. 22:877-882
Overexpression of proteins in Escherichia coli at low temperature improves their solubility and stability. Here, we apply the unique features of the cspA gene to develop a series of expression vectors, termed pCold vectors, that drive the high expres
Autor:
Frances K. Tong, Kit I. Tong, Fumio Yoshikawa, Ivan Bosanac, Miwako Iwai, Tapas K. Mal, Teiichi Furuichi, Takayuki Michikawa, Susanna Talarico, Katsuhiko Mikoshiba, Jenny Chan, Jean René Alattia, Mitsuhiko Ikura
Publikováno v:
Nature. 420:696-700
In a variety of cells, the Ca2+ signalling process is mediated by the endoplasmic-reticulum-membrane-associated Ca2+ release channel, inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Being ubiquitous and present in organisms ranging from human
Autor:
Kevin Truong, Mitsuhiko Ikura
Publikováno v:
Journal of Structural and Functional Genomics. 2:135-143
The cadherin superfamily is a large protein family with diverse structures and functions. Because of this diversity and the growing biological interest in cell adhesion and signaling processes, in which many members of the cadherin superfamily play a