Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michael J. Welsh"'
Autor:
Michael McMenamy, F. McNeilly, John McKillen, Gordon Allan, Catherine Duffy, Michael J. Welsh, I. McNair
Publikováno v:
Archives of Virology. 156:2157-2162
The production, preliminary characterisation and applications of monoclonal antibodies (mAbs) against two novel swine bocaviruses isolated in cell culture from swine in Northern Ireland are described. Of the 17 stable final clones produced, four were
Autor:
John A. Wemmie, Sandra Vergo, Michael J. Welsh, Lars Fugger, Matthew Craner, Ruth Etzensperger, Angela Vincent, Manuel A. Friese
Publikováno v:
Friese, MA, Cramer, MJ, Etzensperger, R, Vergo, S, Wemmie, JA, Welsh, MJ, Vincent, A & Fugger, L H 2007, ' Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system ', Nat. Med, vol. 13, no. 12, pp. 1483-1489 .
Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration. The neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) is permeable to Na+ and Ca2+, and excessive accumulation of these ions is associated with
Autor:
Qian Dong, Michael J. Welsh, Changsoo Kim, Lei Liu, Runping Wang, Yuhong Li, Huey Hing, Chong Yin
Publikováno v:
Nature. 450:294-298
Since the early years of the last century, it has been known that many organisms possess the ability to detect ambient humidity. For some organisms, this ability is crucial for survival. Because their small body size makes them particularly susceptib
Autor:
Michael J. Welsh, Christoph O. Randak
Publikováno v:
Journal of Bioenergetics and Biomembranes. 39:473-479
The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(-)channel in the ATP-binding cassette (ABC) transporter protein family. CFTR features the modular design characteristic of ABC transporters, which includes two membrane-spanning d
Autor:
Joseph Zabner, Paola D. Vermeer, Thomas O. Moninger, Michael J. Welsh, Jeffrey A. Kern, Tatiana Rokhlina, Lisa A. Einwalter
Publikováno v:
Nature. 422:322-326
Interactions between ligands and receptors are central to communication between cells and tissues. Human airway epithelia constitutively produce both a ligand, the growth factor heregulin, and its receptors--erbB2, erbB3 and erbB4 (refs 1-3). Althoug
Publikováno v:
Nature. 417:552-555
Antimicrobial factors form one arm of the innate immune system, which protects mucosal surfaces from bacterial infection. These factors can rapidly kill bacteria deposited on mucosal surfaces and prevent acute invasive infections. In many chronic inf
Autor:
Heather A. Drummond, Ron F. Hrstka, Annne G. Mannsfeldt, Jing Qiao, Paul A. Heppenstall, Sabrina L. McIlwrath, Gary R. Lewin, Baoli Yang, Margaret P. Price, Christopher J. Benson, Roger A. Williamson, Delrdre E. Tarr, Michael J. Welsh, Cheryl L. Stucky, Jinghui Xie, Timothy J. Brennan, Chun Cheng
Publikováno v:
Nature. 407:1007-1011
Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1)
Publikováno v:
Gene Therapy. 4:1173-1180
Complexes of DNA and cationic lipid offer potential advantages for gene transfer to airway epithelia. However, we found that application of DNA-lipid (DMRIE-DOPE) complexes to primary cultures of human ciliated airway epithelia or explants of rabbit
Autor:
Richard J. Gregory, Devra P. Rich, David N. Sheppard, Lynda S. Ostedgaard, Michael J. Welsh, Alan E. Smith
Publikováno v:
Nature. 362:160-164
The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation-regulated Cl- channel located in the apical membrane of epithelia. Although cystic fibrosis (CF) is caused by mutations in a single gene encoding CFTR, the disease ha
Autor:
John Marshall, Jane F. Amara, Alan E. Smith, Michael J. Welsh, Matthew P. Anderson, Gerene M. Denning
Publikováno v:
Nature. 358:761-764
Cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane Cl- channel regulated by cyclic AMP-dependent phosphorylation and by intracellular ATP. Mutations in CFTR cause cystic fibrosis partly through loss of cAMP-regulated Cl-