Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jose R. Conejo-Garcia"'
Autor:
Alexandra L. Martin, Chase Powell, Mate Z. Nagy, Patrick Innamarato, John Powers, Derek Nichols, Carmen M. Anadon, Ricardo A. Chaurio, Sungjune Kim, Min-hsuan Wang, Bing Gong, Xianzhe Wang, Thomas J. Scheutz, Scott J. Antonia, Jose R. Conejo-Garcia, Bradford A. Perez
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1445-1460
Publikováno v:
Nature Reviews Urology. 18:543-555
The advent of immune checkpoint inhibition (ICI) has transformed the treatment paradigm for bladder cancer. However, despite the success of ICI in other tumour types, the majority of ICI-treated patients with bladder cancer failed to respond. The lac
Autor:
Carmen M. Anadon, Shelley S. Tworoger, Alexander R. A. Anderson, Robert M. Wenham, Ricardo A. Chaurio, Mary K. Townsend, Paulo C. Rodriguez, Xiaoqing Yu, Naoko Sasamoto, Carlos Moran, Andrea L. Buras, Jimena Trillo-Tinoco, Tara Lee Costich, Jose R. Conejo-Garcia, Jessica A. Mine, Subir Biswas, Chandler Gatenbee, Kathryn L. Terry, Kristen E. Rigolizzo, Douglas Marchion, Kyle K. Payne, Gunjan Mandal, Carly M. Harro
Publikováno v:
Nature. 591:464-470
Most ovarian cancers are infiltrated by prognostically relevant activated T cells1–3, yet exhibit low response rates to immune checkpoint inhibitors4. Memory B cell and plasma cell infiltrates have previously been associated with better outcomes in
Publikováno v:
Nature Cancer. 3:657-658
Autor:
Tamas Ordog, Krutika S. Gaonkar, David W. Speicher, Ronny Drapkin, Shuai Wu, Pyoung Hwa Park, Jeong Heon Lee, Benjamin G. Bitler, Sergey Karakashev, Huihuang Yan, Yuhki Yokoyama, Jose R. Conejo-Garcia, Andrew V. Kossenkov, Rugang Zhang, Hengrui Zhu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers. However, clinically applicable cancer therapeutic strategies based on CARM1 expression rem
Autor:
Paul J. Zhang, Alfredo Perales-Puchalt, Carl H. June, Julia Tchou, Jose R. Conejo-Garcia, Yun Li, Amy Ziober, Rena R. Xian
Publikováno v:
Breast Cancer Research and Treatment. 147:675-684
Mesothelin is a potential therapeutic target and prognostic marker in breast cancer. However, results on its prognostic value in breast cancer have been equivocal and warranted further evaluation. We analyzed clinical data from two breast cancer pati
Autor:
Anna Wasiuk, Dyana K. Dalton, William L. Schpero, Jose R. Conejo-Garcia, Randolph J. Noelle, Radu V. Stan
Publikováno v:
Cancer Immunology, Immunotherapy. 61:2273-2282
Mast cells have emerged as critical intermediaries in the regulation of peripheral tolerance. Their presence in many precancerous lesions and tumors is associated with a poor prognosis, suggesting mast cells may promote an immunosuppressive tumor mic
Autor:
Carl H. June, Michael Kalos, Hossein Borghaei, Liang-Chuan Wang, Paul J. Zhang, Ben Selven, Jose R. Conejo-Garcia, Hongtao Zhang, Robert H. Vondeheide, Julia Tchou, Steven M. Albelda
Publikováno v:
Breast Cancer Research and Treatment. 133:799-804
Mesothelin is a cell-surface glycoprotein present on mesothelial cells and elicits T cell responses in a variety of cancers including pancreatic, biliary and ovarian cancer. Breast cancer is not known to express mesothelin. We postulated that mesothe
Publikováno v:
British Journal of Cancer
In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ov
Autor:
Eugene Kang, Dionyssios Katsaros, Jose R. Conejo-Garcia, George Coukos, Fabian Benencia, Ronald J. Buckanovich, Maria C. Courreges, Daniel S. Wagner, Alisha Mohamed-Hadley, Richard Caroll, Ann Jenkins, Hana Na, Lin Zhang, David O. Holtz
Publikováno v:
Nature Medicine. 10:950-958
The involvement of immune mechanisms in tumor angiogenesis is unclear. Here we describe a new mechanism of tumor vasculogenesis mediated by dendritic cell (DC) precursors through the cooperation of beta-defensins and vascular endothelial growth facto