Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jonathan V. Sweedler"'
Autor:
James Eberwine, Junhyong Kim, Ron C. Anafi, Steven Brem, Maja Bucan, Stephen A. Fisher, M. Sean Grady, Amy E. Herr, David Issadore, Hyejoong Jeong, HyunBum Kim, Daeyeon Lee, Stanislav Rubakhin, Jai-Yoon Sul, Jonathan V. Sweedler, John A. Wolf, Kenneth S. Zaret, James Zou
Publikováno v:
Nat Methods
We argue that the study of single-cell subcellular organelle omics is needed to understand and regulate cell function. This requires and is being enabled by new technology development.
Autor:
Roland Hellinger, Arnar Sigurdsson, Wenxin Wu, Elena V. Romanova, Lingjun Li, Jonathan V. Sweedler, Roderich D. Süssmuth, Christian W. Gruber
Publikováno v:
Nature Reviews Methods Primers. 3
Autor:
Daniel C. Castro, Yuxuan Richard Xie, Stanislav S. Rubakhin, Jonathan V. Sweedler, Elena V. Romanova
Publikováno v:
Nature Methods. 18:1233-1238
Peptidergic dense-core vesicles are involved in packaging and releasing neuropeptides and peptide hormones—critical processes underlying brain, endocrine and exocrine function. Yet, the heterogeneity within these organelles, even for morphologicall
Autor:
Ahmed Ali, Shawn Davidson, Ernest Fraenkel, Ian Gilmore, Thomas Hankemeier, Jennifer A. Kirwan, Andrew N. Lane, Ingela Lanekoff, Mioara Larion, Laura-Isobel McCall, Michael Murphy, Jonathan V. Sweedler, Caigang Zhu
Publikováno v:
Metabolomics
Metabolomics, 18(10):77. SPRINGER
Metabolomics, 18(10):77. SPRINGER
BACKGROUND: Single cell metabolomics is an emerging and rapidly developing field that complements developments in single cell analysis by genomics and proteomics. Major goals include mapping and quantifying the metabolome in sufficient detail to prov
Autor:
Amynah A. Pradhan, Jonathan V. Sweedler, Bruce R. Southey, Pan Zhang, Sandra L. Rodriguez-Zas, Laura S. Moye, Isaac Dripps
Publikováno v:
Mol Neurobiol
The benefits of opioid-based treatments to mitigate chronic pain can be hindered by the side effects of opioid-induced hyperalgesia (OIH) that can lead to higher consumption and risk of addiction. The present study advances the understanding of the m
Autor:
Xi Chen, Michael J. T. Stubbington, J. Christopher Love, Valentine Svensson, Nicholas Navin, Lior Pachter, Jonathan V. Sweedler, Sarah A. Teichmann
Publikováno v:
Nature Biotechnology. 34:1111-1118
Autor:
John E. Cronan, Matthew P. Jacobson, Suwen Zhao, B. Hillerich, Jonathan V. Sweedler, Ayano Sakai, Patricia C. Babbitt, Steven C. Almo, Matthew W. Vetting, Shoshana D. Brown, R.D. Seidel, John A. Gerlt, Jeffery B. Bonanno, Ritesh Kumar, B. Mc Kay Wood
Publikováno v:
Nature
Assigning valid functions to proteins identified in genome projects is challenging: overprediction and database annotation errors are the principal concerns. We and others are developing computation-guided strategies for functional discovery with 'me
Publikováno v:
SCIENTIFIC REPORTS(6)
Scientific Reports
Scientific Reports
The integration of microfluidic devices—which efficiently handle small liquid volumes—with separations/mass spectrometry (MS) is an effective approach for profiling the neurochemistry occurring in selected neurons. Interfacing the microfluidic ce
Publikováno v:
Cellular and Molecular Bioengineering. 5:155-164
Growing experimental evidence suggests that mechanical tension plays a significant role in determining the growth, guidance, and function of neurons. Mechanical tension in axons contributes to neurotransmitter clustering at the Drosophila neuromuscul
Autor:
Jonathan V. Sweedler, Lloyd D. Fricker
Publikováno v:
The AAPS Journal. 12:679-682
The proteome and peptidome are defined as the set of proteins and peptides present in a tissue or other biological sample. In most proteomic studies, only abundant proteins are detected and, although these are important molecules, they are often well