Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jingwu Xie"'
Autor:
Dongsheng Gu, Arvin H Soepriatna, Wenjun zhang, Jun Li, jenny Zhao, xiaoli Zhang, xianhong Shu, yongshi Wang, Benjamin J Landis, Craig J Goergen, jingwu Xie
Publikováno v:
Cell & Bioscience. 13
Background Fibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal organ function and contributes to ~ 45% of human mortality. Fibrosis develops in response to chronic
Autor:
E. Gabriela Chiorean, Jingwu Xie, Dongsheng Gu, Beiqin Yu, Jun Wan, Xiaoli Zhang, Yanfei Jia, Yunshan Wang
Publikováno v:
Oncogene
Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most lethal cancers, with a dismal median survival around 8 months. PDAC is notoriously resistant to chemotherapy. Thus far, numerous attempts using novel targeted ther
Autor:
Dongsheng Gu, Xiaoben Liu, Seung Young Lee, Samuel Chen, Bing Song, Jingwu Xie, Shovik Bandyopadhyay, Stephen F. Konieczny, Junjie Li, Ji-Xin Cheng, Timothy L. Ratliff
Publikováno v:
Oncogene
Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumula
Publikováno v:
Archives of Toxicology. 89:179-191
Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in regulation of differentiation, proliferation, tissue polarity, stem c
Publikováno v:
Cell & Bioscience, Vol 7, Iss 1, Pp 1-9 (2017)
Cell & Bioscience
Cell & Bioscience
Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cancer eventually succumb to the disease despi
Publikováno v:
Endocrine Pathology. 22:97-102
Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyr
Publikováno v:
Oncogene. 29:469-481
The hedgehog pathway, initially discovered by two Nobel laureates Drs E Wieschaus and C Nusslein-Volhard in Drosophila, is a major regulator for cell differentiation, tissue polarity and cell proliferation. Studies from many laboratories reveal activ
Autor:
Jingwu Xie
Publikováno v:
Current Oncology Reports. 10:107-113
The hedgehog pathway, initially discovered in Drosophila by two Nobel laureates, Dr. Eric Wieschaus and Dr. Christiane Nüsslein-Volhard, is a major regulator for cell differentiation, tissue polarity, and cell proliferation. Studies from many labora
Autor:
Xiaoli Zhang, Sumin Chi, Stephen K. Tyring, Oivin Guicherit, Jingwu Xie, Chengxin Li, Richard F. Wagner, Nonggao He
Publikováno v:
Oncogene. 23:1608-1617
Basal cell carcinoma (BCC), the most common form of human cancer, is understood to be associated with activation of the sonic hedgehog pathway, through loss-of-function mutations of tumor suppressor PTCH1 or gain-of-function mutations of smoothened.
Autor:
Sui-Fan Tong, Lisa Y.S. Chan, Ka Fai To, Nancy Wah-Fun Yuen, Kam Cheong Lee, Frank McCormick, Jingwu Xie, Ching-Wan Lam, Pak Leong Lim, Ho Keung Ng
Publikováno v:
Oncogene. 18:833-836
Basal-cell carcinomas (BCCs) are the most common cancer in Caucasians. It has been reported that the patched gene is inactivated in 30-40% sporadic BCCs and 20% sporadic medulloblastomas via loss of heterozygosity and nonsense mutations. Recently, tw