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Autor:
Dora Ferrari, Yi Yu, Ronald E. Savage, Marjorie J. Lindhurst, Miranda R. Yourick, Leslie G. Biesecker
Publikováno v:
Scientific Reports
A somatic activating mutation in AKT1, c.49G>A, pGlu17Lys, that results in elevated AKT signaling in mutation-positive cells, is responsible for the mosaic overgrowth condition, Proteus syndrome. ARQ 092 is an allosteric pan-AKT inhibitor under devel