Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dolph L. Hatfield"'
Autor:
Donghyun Kang, Jeeyeon Lee, Jisu Jung, Bradley A. Carlson, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Byung Cheon Lee, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee, Jin-Hong Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Aging and mechanical overload are prominent risk factors for osteoarthritis (OA), which lead to an imbalance in redox homeostasis. The resulting state of oxidative stress drives the pathological transition of chondrocytes during OA development. Howev
Publikováno v:
Nature Protocols. 4:1338-1348
Small hairpin RNA (shRNA) is a powerful tool for inhibiting gene expression. One limitation has been that this technique has been used primarily to target a single gene. This protocol expands upon previous methods by describing a knockdown vector tha
Autor:
Dolph L. Hatfield, Mohamed E. Moustafa, Vyacheslav M. Labunskyy, Vadim N. Gladyshev, Bradley A. Carlson, Sergey V. Novoselov, Valentina M. Factor, Dmitri E. Fomenko, Diego F. Calvisi
Publikováno v:
Oncogene. 24:8003-8011
The micronutrient element selenium (Se) has been shown to be effective in reducing the incidence of cancer in animal models and human clinical trials. Selenoproteins and low molecular weight Se compounds were implicated in the chemopreventive effect,
Publikováno v:
Origins of Life and Evolution of the Biosphere. 29:425-435
We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutiona
Publikováno v:
Protocol Exchange.