Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel D. De Carvalho"'
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications. 14
Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent an impor
Autor:
Vikas Patil, Rupert Hugh-White, Thomas Kislinger, Bharati Mehani, Kenneth Aldape, Daniel D. De Carvalho, Caroline Y. Chen, Andrew Macklin, Ankur Chakravarthy, Qingxia Wei, Gary D. Bader, Lydia Y Liu, Rosario I. Corona, Paul C. Boutros, Adriana M. Workewych, Justin Z. Wang, Suganth Suppiah, Jeffrey C Liu, Yasin Mamatjan, Ghazaleh Tabatabai, Shirin Karimi, Farshad Nassiri, Andrew Gao, Gelareh Zadeh, Olivia Singh, Shahbaz Khan
Publikováno v:
Nature. 597:119-125
Meningiomas are the most common primary intracranial tumour in adults1. Patients with symptoms are generally treated with surgery as there are no effective medical therapies. The World Health Organization histopathological grade of the tumour and the
Autor:
Sujun Chen, Jessica Petricca, Wenbin Ye, Jiansheng Guan, Yong Zeng, Nicholas Cheng, Linsey Gong, Shu Yi Shen, Junjie T. Hua, Megan Crumbaker, Michael Fraser, Stanley Liu, Scott V. Bratman, Theodorus van der Kwast, Trevor Pugh, Anthony M. Joshua, Daniel D. De Carvalho, Kim N. Chi, Philip Awadalla, Guoli Ji, Felix Feng, Alexander W. Wyatt, Housheng Hansen He
Publikováno v:
Nature communications, vol 13, iss 1
Metastatic prostate cancer remains a major clinical challenge and metastatic lesions are highly heterogeneous and difficult to biopsy. Liquid biopsy provides opportunities to gain insights into the underlying biology. Here, using the highly sensitive
Autor:
Helen Loo Yau, Parinaz Mehdipour, Ilias Ettayebi, Charles A. Ishak, Ankur Chakravarthy, Daniel D. De Carvalho, Catherine A. O’Brien, Amir H. Hosseini, Fabíola Attié de Castro, Yadong Wang, Sagi Abelson, Sajid A. Marhon
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor1–6.
Autor:
Karan J. Abraham, Miling Wang, Jack Greenblatt, Lauren A. Ostrowski, Aparna Gorthi, Parasvi S. Patel, Daniel D. De Carvalho, Razq Hakem, Michael Ohh, Roxanne Oshidari, Alexander J.R. Bishop, Violena Pietrobon, Anas Samman, Arash Algouneh, Dorothy Yanling Zhao, Stephen Lee, Michael Bokros, Janet N.Y. Chan, V Talya Yerlici, Rajat Singhania, Brendan C. Dickson, Yupeng Liu, Elva Vidya, Negin Khosraviani, Karim Mekhail
Publikováno v:
Nature
Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the
Publikováno v:
Nature Protocols. 14:2749-2780
Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recently, methylation profiling of cfDNA as a liquid biopsy tool has been gaining prominence due to the prese
Publikováno v:
Nature Reviews Cancer. 19:151-161
DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that have acquired DNA methylation during carcinogenesis, they
Publikováno v:
Nature Cancer. 2:1000-1001
DNA methyltransferase inhibitors are widely used in preclinical and clinical studies, but poor pharmacokinetics and low efficacy in solid tumors limit their therapeutic use. A new study reports the development and characterization of a specific, non-
Autor:
Reema Deol, Tiago Medina, Rahul Shinde, Marie Jo Halaby, Yuriy Baglaenko, Zahi Touma, Sathi Babu Chodisetti, Kieran P. Manion, Haiyun Liu, Maria Eldh, Sara Lamorte, Kapil Chaudhary, Andreas Kloetgen, Drew Wallace, Kebria Hezaveh, Tracy L. McGaha, Ankur Chakravarthy, Aristotelis Tsirigos, David H. Munn, Joan E. Wither, Susanne Gabrielsson, Michael P. Madaio, Daniel D. De Carvalho, Buvana Ravishankar
Publikováno v:
Nature Immunology. 19:571-582
The transcription factor AhR modulates immunity at multiple levels. Here we report that phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of the cytokine IL-10. Activation of AhR was dependent on interact
Autor:
Parinaz Mehdipour, Helen Loo Yau, Yadong Wang, Daniel D. De Carvalho, Amir H. Hosseini, Sagi Abelson, Fabíola Attié de Castro, Ankur Chakravarthy, Ilias Ettayebi, Sajid A. Marhon, Catherine A. O’Brien, Charles A. Ishak
Publikováno v:
Nature. 591:E20-E20