Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jan Tavernier"'
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
Autor:
Emilie Caron, Rubén Nogueiras, Ulrich Boehm, Manon Duquenne, Markus Schwaninger, Jerome Clasadonte, Cyril Bourouh, Eleonora Deliglia, Stéphane Ory, Young-Bum Kim, Stéphane Gasman, Eric Trinquet, Soumya Kusumakshi, Asturo Oishi, Massimiliano Mazzone, S. Rasika, Daniela Fernandois, Nathalie Jouy, Jan Tavernier, Cintia Folgueira, Marion Millet, Anisia Silva, Julie Dam, Ines Martinez-Corral, Ralf Jockers, Monica Imbernon, Vincent Prevot, Jean-Sébastien Annicotte
Publikováno v:
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2021, 3 (8), pp.1071-1090. ⟨10.1038/s42255-021-00432-5⟩
Nature metabolism
Nature Metabolism, Nature Publishing Group, 2021, 3 (8), pp.1071-1090. ⟨10.1038/s42255-021-00432-5⟩
Nature metabolism
Metabolic health depends on the brain’s ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain barriers and mobilize regulatory circuit
Autor:
Lode De Cauwer, Claude Libert, Sam Lievens, Jonathan Thommis, Nadia Bougarne, Jan Tavernier, Marlies Ballegeer, Sofie Desmet, Ioanna Petta, Lien Dejager, Sofie Vandevyver, Karolien De Bosscher, Jolien Vandewalle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s l
Autor:
K. De Bosscher, Jonathan Thommis, Marnik Vuylsteke, Nadia Bougarne, Sofie Desmet, René Houtman, Dariusz Ratman, Jan Tavernier, L. De Cauwer, L. Van de Moortel
Publikováno v:
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in variou
Autor:
Savvas N. Savvides, Jan Tavernier, Yehudi Bloch, Frank Peelman, Laurens Vyncke, Loes van Schie, Ewald Pauwels, Kenneth Verstraete
Publikováno v:
Nature Structural & Molecular Biology. 21:375-382
Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediat
Publikováno v:
Cellular and Molecular Life Sciences. 65:2964-2978
Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of distinct transcription factors such as nuclear factor-kappaB (NF-k
Autor:
Irma Lemmens, Annick Verhee, Sven Eyckerman, José Van der Heyden, Xaveer Van Ostade, Jan Tavernier, Joël Vandekerckhove
Publikováno v:
Nature Cell Biology. 3:1114-1119
Ligand-induced clustering of type I cytokine receptor subunits leads to trans-phosphorylation and activation of associated cytosolic janus kinases (JAKs). In turn, JAKs phosphorylate tyrosine residues in the receptor tails, leading to recruitment and
Autor:
Hansruedi Loetscher, Jan Tavernier, Walter Fiers, Werner Lesslauer, Reiner L. Gentz, Peter Vandenabeele, Xaveer Van Ostade, Bart Everaerdt, Manfred Brockhaus, Peter Brouckaert
Publikováno v:
ResearcherID
The remarkable ability of tumour necrosis factor (TNF), especially in combination with interferon, selectively to kill or inhibit malignant cell lines is so far unmatched by any other combination of cytokines. But clinical trials in cancer patients h