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Publikováno v:
Pharmacological Reports. 61:1206-1210
Angiotensin II (Ang II) administered intracerebroventriculary (icv) at a dose that induces drinking behavior in rats significantly increased K(+)-stimulated release of [(3)H] noradrenaline (NA) in hypothalamus without affecting basal [(3)H] NA releas
Publikováno v:
Neuroscience and Behavioral Physiology. 39:819-823
The aim of the present work was to study the involvement of glucocorticoid receptors and corticotropin-releasing factor type 2 receptors (CRF-2 receptors) in mediating the analgesic effects of CRF on somatic pain sensitivity. The involvement of gluco
Autor:
Katja Trinkaus, Katrin S. Lips, Christian Heiss, Volker Alt, Brigitte Stigler, Olaf Kilian, Reinhard Schnettler, Maryam En-Nosse, Sonja Hartmann
Publikováno v:
Cell and Tissue Research. 338:203-215
Acetylcholine (ACh) is detected in a variety of non-neuronal cells where it acts as a para/autocrine signaling molecule controlling basic cell functions such as proliferation, differentation, and maintenance of cell-cell contacts. ACh-synthesizing en
Autor:
M. M. Artem’eva, I. A. Kheyfets, M. V. Kachanova, S. A. Sergeeva, O. I. Epshtein, L. B. Sabanov, Yu. A. Zabolotneva, Yu. L. Dugina, N. A. Medvedeva
Publikováno v:
Bulletin of Experimental Biology and Medicine. 148:520-523
Kardos, a preparation containing ultralow doses of antibodies to C-terminal fragment of type 1 receptor of angiotensin II, intragastrically administered to SHR rats with hereditary hypertension for 28 days reduced blood pressure by 14.8%. Kardos was
Publikováno v:
Journal of Neural Transmission
Successful adaptation to stress involves actions of glucocorticoid receptor (GR), a steroid-dependent transcription factor, abundant in hippocampus. Another transcription factor, nuclear factor kappa B (NF kappa B) is considered as an important stres
Autor:
Takayoshi Masuoka, Chiaki Kamei
Publikováno v:
Psychopharmacology. 206:259-265
Nicotine receptors in the brain are closely related with memory amelioration induced by cholinesterase inhibitors.The present study was undertaken to clarify the role of nicotinic receptors in the ameliorative effects of cholinesterase inhibitors on
Publikováno v:
Psychopharmacology. 206:403-414
5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. The aim of this study was to investigate the involvement of 5-HT receptor mechanisms in sub-chronic phencyclidine (PCP)-induced reversal learning defi
Publikováno v:
European Archives of Psychiatry and Clinical Neuroscience. 260:151-162
Altered neuroplasticity contributes to the pathophysiology of schizophrenia. However, the idea that antipsychotics may act, at least in part, by normalizing neurogenesis has not been consistently supported. Our study seeks to determine whether hippoc
Publikováno v:
Cardiovascular Drugs and Therapy. 23:271-280
Prolonged sympathetic activation is damaging to the heart and experimental norepinephrine (NE) infusion induces the deposition of myocardial collagen. This study investigated the effects of NE on collagen and transforming growth factor-beta1 (TGF-bet
Publikováno v:
Pharmacological Reports. 61:727-731
Biphalin, is a palindromic peptide [(Tyr-D-Ala-Gly-Phe-NH-)2] in which two opioid pharmacophores are connected "tail-to-tail". This peptide displays a broad affinity for all opioid receptors (mu, delta and kappa) as well as exceptionally high antinoc