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Autor:
Philipp Gabriel, Aida Salameh, Beate Rassler, Christian Bölter, Peter Appelt, Nicole Fiedler, Katrin Schierle
Publikováno v:
Pflugers Archiv
Acute normobaric hypoxia may induce pulmonary injury with edema (PE) and inflammation. Hypoxia is accompanied by sympathetic activation. As both acute hypoxia and high plasma catecholamine levels may elicit PE, we had originally expected that adrener
Publikováno v:
Experimental Brain Research. 239:2435-2444
Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to
Autor:
Sobia Ahsan Halim, Rukhsana Ghaffar, Ahmed Al-Harrasi, Nasiara Karim, Waqar Ahmad, Ajmal Khan, Imran Khan, Nouman Altaf, Abeer Abdelhalim
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 394:929-940
Cisplatin-induced peripheral neuropathic pain is a common adverse effect of chemotherapy. The present study evaluated the effects of 2'-chloro-6-methylflavone (2'-Cl-6MF) at recombinant α1β2γ2L, α2β1-3γ2L, and α3β1-3γ2L GABA-A receptor subty
Autor:
Raphael Mechoulam, Stephen A Collins, Cheryl L. Limebeer, Linda A. Parker, Megan T. Sullivan, Hannah Goodman, Erin M. Rock
Publikováno v:
Psychopharmacology. 237:2621-2631
When acutely administered intraperitoneally, the non-psychoactive cannabinoid cannabidiol (CBD), its acidic precursor cannabidiolic acid (CBDA) and a stable methyl ester of CBDA (HU-580) reduce lithium chloride (LiCl)–induced conditioned gaping in
Autor:
Li Hu, Jian Cai, Yinggang Sun, Jiaxiang Wu, Fuxue Chen, Jijiang Wang, Shutian Zhang, Kokwin Ooi, Xuehai Wu, Danian Zhu, Chunmei Xia
Publikováno v:
Neuroscience Bulletin
Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla (RVLM) have been implicated in stress-induced hypertension (SIH). Prorenin, a member of the brain renin-angiotensin system
Autor:
Ruth Ibán-Arias, Niki Mastrodimou, Achille Gravanis, Silvia Lisa, Ioannis Charalampopoulos, Kyriaki Thermos, Smaragda Poulaki
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 257:2429-2436
Diabetic retinopathy (DR) is a complex eye disease associated with diabetes mellitus. It is characterized by three pathophysiological components, namely microangiopathy, neurodegeneration, and inflammation. We recently reported that intraperitoneal a
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in initiating vascular inflammation; however, its cellular source in the injured vasculatures is unclear. Given the importance of high mobility group box 1 (HMGB1) in tissue injury, w
Autor:
Christopher Bishop, Nicole E. Chambers, Katherine Chemakin, Carolyn Saito, Sarah Lefkowitz, Kathryn Lanza
Publikováno v:
Psychopharmacology. 237:155-165
In the majority of Parkinson’s disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of s
Publikováno v:
Biological Trace Element Research. 195:499-505
The potential gonadal protective effect of diacerein (DCN) and its underlying mechanisms were studied in a rat model of cadmium-induced testicular toxicity. The rats received DCN (50 mg/kg/day, p.o.) for 10 days and one injection of CdCl2 (2 mg/kg, i
Autor:
Mohammad Alsalem, Mansour Haddad, Manal A. Abbas, Ahmad A. Altarifi, Sahar M. Jaffal, Heba Kalbouneh, Nour Aldaoud, Sara A. Aldossary, Khalid El-Salem
Publikováno v:
Inflammopharmacology. 27:1131-1142
Osteoarthritis (OA) is characterized by cartilage degeneration, subchondral sclerosis, and pain. Cannabinoids have well-established anti-nociceptive properties in animal models of chronic pain. The aim of this study is to evaluate the anti-nociceptiv