Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David Lyden"'
Autor:
Jinxiang Dai, Patrick J. Cimino, Kenneth H. Gouin, Candice A. Grzelak, Alexander Barrett, Andrea R. Lim, Annalyssa Long, Stephanie Weaver, Lindsey T. Saldin, Aiyedun Uzamere, Vera Schulte, Nigel Clegg, Laura Pisarsky, David Lyden, Mina J. Bissell, Simon Knott, Alana L. Welm, Jason H. Bielas, Kirk C. Hansen, Frank Winkler, Eric C. Holland, Cyrus M. Ghajar
Publikováno v:
Nature Cancer. 3:25-42
Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell (DTC) dormancy in this organ is limited. Here using serial intravital i
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Publikováno v:
Nature Cell Biology. 23:111-113
Anorexia commonly develops in patients with advanced cancer and is closely associated with cachexia. A new study shows that anorexia emerges earlier than cachexia in both Drosophila and mouse tumour models and that tumour-derived humoral factors indu
Autor:
David Lyden, Giacomo Canesin, Gema Moreno-Bueno, Francisco Portillo, Vanesa Santos, Eva P. Cuevas, Héctor Peinado, Celia López-Menéndez, Amparo Cano, Katalin Csiszar, Yujie Huang
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Epithelial-mesenchymal transition (EMT) has been associated with increased aggressiveness and acquisition of migratory properties providing tumor cells with the ability to invade into adjacent tissues. Downregulation of E-cadherin, a hallmark of EMT,
Autor:
Mark J. Tomishima, Daniel J. Nolan, Daylon James, Nikica Zaninovic, Marco Seandel, Shahin Rafii, Sina Y. Rabbany, Lorenz Studer, Tyler Janovitz, David Lyden, Robert Benezra, Hyung Song Nam, Zev Rosenwaks, Gabsang Lee
Publikováno v:
Nature Biotechnology. 28:161-166
Previous efforts to differentiate human embryonic stem cells (hESCs) into endothelial cells have not achieved sustained expansion and stability of vascular cells. To define vasculogenic developmental pathways and enhance differentiation, we used an e
Publikováno v:
Cancer and Metastasis Reviews. 25:521-529
Metastasis, the spread of invasive carcinoma to sites distant from the primary tumor, is responsible for the majority of cancer-related deaths (Weigelt, B., Peterse, J. L., & van 't Veer, L. J. (2005). Breast cancer metastasis: Markers and models. Na
Autor:
Shahin Rafii, David Lyden
Publikováno v:
Nature Medicine. 9:702-712
Emerging evidence suggests that bone marrow‐derived endothelial, hematopoietic stem and progenitor cells contribute to tissue vascularization during both embryonic and postnatal physiological processes. Recent preclinical and pioneering clinical st
Publikováno v:
Nature Reviews Cancer. 2:826-835
Summary Tumours recruit neighbouring blood vessels and vascular endothelial cells to support their own blood supply. Recent evidence has indicated, however, that tumours are also capable of mobilizing bone-marrow-derived endothelial precursor cells,