Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Richard A, Koup"'
Autor:
Srinivas S. Rao, Jason Hataye, Keyun Wang, Joseph P. Casazza, Tongqing Zhou, Lan Wu, Zhi Yong Yang, Amarendra Pegu, Wei Shi, Richard A. Koup, John Paul Todd, Peter D. Kwong, Gary J. Nabel, Ivelin S. Georgiev, Xiaoti Guo, Xuejun Chen, Mangaiarkarasi Asokan, Sijy O'Dell, John R. Mascola
Publikováno v:
Nature Communications
The treatment of AIDS with combination antiretroviral therapy (cART) remains lifelong largely because the virus persists in latent reservoirs. Elimination of latently infected cells could therefore reduce treatment duration and facilitate immune reco
Autor:
Padma Malyala, Stephen D. Schmidt, Sam Darko, Rebecca M. Lynch, Lawrence Shapiro, Nicholas Valiante, Nisc Comparative Sequencing Program, Yoshiaki Nishimura, John R. Mascola, Robert A. Seder, Takuya Yamamoto, Malcolm A. Martin, Daniel C. Douek, Ennio De Gregorio, David Wolinsky, Manmohan Singh, Thomas B. Kepler, Barbara J. Flynn, Martha Nason, Zizhang Sheng, Rodrigo Matus-Nicodemos, Brandon F. Keele, Susan W. Barnett, Masashi Shingai, Akshaya Ramesh, Richard A. Koup, Joseph R. Francica, Zhenhai Zhang, Derek T. O'Hagan
Publikováno v:
Nature Communications
Developing predictive animal models to assess how candidate vaccines and infection influence the ontogenies of Envelope (Env)-specific antibodies is critical for the development of an HIV vaccine. Here we use two nonhuman primate models to compare th
Autor:
Arik Cooper, Mayra Garcia, Takuya Yamamoto, Richard A. Koup, Constantinos Petrovas, Gary J. Nabel
Publikováno v:
Retrovirology
Human immunodeficiency virus-1 (HIV-1) has infected more than 60 million people and caused nearly 30 million deaths worldwide, ultimately the consequence of cytolytic infection of CD4(+) T cells. In humans and in macaque models, most of these cells c
Autor:
Dolores M. Peterson, Mark Connors, Louis J. Picker, Christine J. Pitcher, Vernon C. Maino, Richard A. Koup, Claudia Quittner
Publikováno v:
Nature Medicine. 5:518-525
The role of HIV-1-specific CD4+ T-cell responses in controlling HIV-1 infection remains unclear. Previous work has suggested that such cells are eliminated in the early stages of infection in most subjects, and thus cannot substantially contribute to
Autor:
Dennis R. Burton, Marie Claire Gauduin, Raymond Weir, Paul W. H. I. Parren, Carlos F. Barbas, Richard A. Koup
Publikováno v:
Nature Medicine. 3:1389-1393
How well antibodies can protect against disease due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine design and the use of prophylactic antibody to prevent infection after accidental exposure to the vi
Autor:
William A. Paxton, Richard A. Koup
Publikováno v:
Springer Seminars in Immunopathology. 18:323-340
The global expansion of the HIV-1 pandemic represents one of the world’s most pressing public health problems. HIV-1 has spread from the sites of the original epidemic in Africa, North America and Europe to involve all corners of the globe. This in