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Autor:
Jace Jones-Tabah, Hanan Mohammad, Ryan D. Martin, Lucy E. H. Kim, Faiza Benaliouad, Shadi Hadj-Youssef, Paul B. S. Clarke, Terence E. Hébert, Jason C. Tanny
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
As with many G protein-coupled receptors (GPCRs), the signalling pathways regulated by the dopamine D1 receptor (D1R) are dynamic, cell type-specific, and can change in the face of disease or drug exposures. In striatal neurons, the D1R activates cAM
Autor:
Carolina Demarchi Munhoz, Ana Paula Cremasco Takano, Nathalia Senger, Maria Luiza Morais Barreto-Chaves
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:549-558
We have previously demonstrated that calcium-binding protein S100A8 and myeloid differentiation factor-88 (MyD88) are important mediators of nuclear transcription factor kappa-B (NF-κB) activation in cardiomyocytes and that signalling molecules are
Publikováno v:
Reproductive Sciences. 21:41-51
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are expressed in the hypothalamus, the gonadotrope cells of the anterior pituitary gland, and the gonads, forming an autocrine–paracrine system in these tissues. Within th
Autor:
Ajeesh Balakrishnan-Renuka, Beate Brand-Saberi, Helmut E. Meyer, Corinna Henkel, Lisa Wessel, Carsten Theiss, Karl Meller
Publikováno v:
Cellular and Molecular Life Sciences. 71:1723-1740
Cerebellar Purkinje cells (PC) physiologically reveal an age-dependent expression of progesterone with high endogenous concentrations during the neonatal period. Even if progesterone has been previously shown to induce spinogenesis, dendritogenesis a
Autor:
Jin-Rui Chang, Yong-Fen Qi, Yan-Rong Yu, Ye-bo Zhou, Chaoshu Tang, Mo-Zhi Jia, Yan Cai, Youfei Guan, Jing Zhang, Ding-Qiong Peng, Wei Wu
Publikováno v:
Cell Biochemistry and Biophysics. 66:421-429
Peroxisome proliferator-activated receptor γ (PPARγ) and its ligands have profound effects on glucose homeostasis, cardiovascular diseases, and bone metabolism. To explore the pathophysiological roles of PPARγ in diabetes with concomitant vascular
Autor:
Peng-zhou Hang, Hong-mei Han, Shu Wang, Yan Liu, Zhimin Du, Hao-xin Song, Zhenwei Pan, Ya-nan Jiang, Lihua Sun
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 385:823-831
Choline, an agonist of M(3) muscarinic acetylcholine receptors, is a precursor and metabolite of acetylcholine and is also a functional modulator of cellular membrane. However, the effect of choline on cardiac hypertrophy is not fully understood. The
Autor:
Hai Wang, Rui-jun Zhao
Publikováno v:
Acta Pharmacologica Sinica. 32:573-580
Aim: To elucidate the modulation of the chemerin/ChemR23 axis by iptakalim-induced opening of K ATP channels and to determine the role of the chemerin/ChemR23 axis in the iptakalim-mediated endothelial protection. Methods: Cultured rat aortic endothe
Autor:
Tie-Bing Zhu, Kejiang Cao, Ling Yan, Zhengxian Tao, Zhijian Yang, Lian-Sheng Wang, Jun Huang, Shi-Yang Pan
Publikováno v:
Molecular Biology Reports. 38:2695-2701
Calcium-sensing receptors (CaSR) are G-protein coupled receptors which maintain systemic calcium haemeostasis, participate in hormone secretion, activation of iron channel, cell apoptosis, proliferation and differentiation. Previous studies have show
Autor:
Koichi Yamamoto, Ryosuke Oguro, Atsushi Shiota, Yuji Tatara, Masao Takeda, Yasushi Takeya, Mitsuru Ohishi, Norihiro Hayashi, Yoshihiro Iwamoto, Hiromi Rakugi
Publikováno v:
Hypertension Research. 33:1182-1185
To clarify the role of endogenous angiotensin (Ang)-converting enzyme 2 (ACE2) and its cleavage product, Ang 1-7, in the atherogenic stimulation of vascular cells, we investigated the effect of pharmacological inhibition of ACE2 and Mas, an Ang 1-7 r
Publikováno v:
Bulletin of Experimental Biology and Medicine. 149:40-43
Melatonin (5 nM) added to medium with primary hepatocyte cultures shifted the phase of circahoralian rhythm of protein synthesis and hence, can be a factor synchronizing fluctuations in protein synthesis and rhythm organizer in the hepatocyte populat