Zobrazeno 1 - 10
of 50
pro vyhledávání: '"11"'
Autor:
Joana Almeida Palha, Tiago Gil Oliveira, Margarida Correia-Neves, Sandro Da Mesquita, Fernanda Marques, João Carlos Sousa, Ana Mendanha Falcão, Ana C. Ferreira, Nuno Sousa
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The production, accumulation and aggregation of amyloid beta (Aß) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyl
Publikováno v:
Cell death and differentiation
Under inflammatory conditions, neutrophil apoptosis is delayed due to survival-factor exposure, a mechanism that prevents the resolution of inflammation. One important proinflammatory cytokine involved in the regulation of neutrophil survival/activat
Publikováno v:
Cell Death & Disease
Mediators produced by the airway epithelium control the activation, recruitment, and survival of pulmonary dendritic cells (DC) that present antigen to CD4(+) T cells during the genesis and exacerbation of allergic asthma. The epithelial-derived acut
Autor:
Wen-wen Cong, Yenan Feng, Han Xiao, Jing Shen, Shuai-Xing Wang, Zijian Li, Ming Xu, Youyi Zhang, Guomin Hu, Erdan Dong, Mingzhe Li, Jimin Wu
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-11 (2020)
Cell Death & Disease
Cell Death & Disease
Acute sympathetic stress quickly induces cardiac inflammation and injury, suggesting that pathogenic signals rapidly spread among cardiac cells and that cell-to-cell communication may play an important role in the subsequent cardiac injury. However,
Autor:
Satoshi Kojo, Arinze Okeke, Terumi Kohwi-Shigematsu, Wooseok Seo, Shin ichiro Fujii, Ichiro Taniuchi, Kanako Shimizu
Publikováno v:
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. Here we identify two stage-specific enhan
Autor:
Christopher M. Rice, Tracey A. Rouault, Richard M. Higashi, Teresa Cassel, Andrew N. Lane, Nunziata Maio, David A. Wink, Daniel W. McVicar, Marieli Gonzalez-Cotto, Teresa W.-M. Fan, Walter A. Baseler, Luke C. Davies, Erika M. Palmieri, Bart Ghesquière
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Palmier, E M, Gonzalez-Cotto, M, Baseler, W A, Davies, L C, Ghesquière, B, Maio, N, Rice, C M, Rouault, T A, Cassel, T, Higashi, R M, Lane, A N, Fan, T W-M, Wink, D A & McVicar, D W 2020, ' Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. ', Nature Communications, vol. 11, 698 (2020) . https://doi.org/10.1038/s41467-020-14433-7
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Palmier, E M, Gonzalez-Cotto, M, Baseler, W A, Davies, L C, Ghesquière, B, Maio, N, Rice, C M, Rouault, T A, Cassel, T, Higashi, R M, Lane, A N, Fan, T W-M, Wink, D A & McVicar, D W 2020, ' Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. ', Nature Communications, vol. 11, 698 (2020) . https://doi.org/10.1038/s41467-020-14433-7
Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) produced by murine macrophages is responsible for TCA cycle alterations an
Publikováno v:
Journal of Molecular Histology. 37:101-113
In type 1 diabetes mellitus (T1DM), the processes which control the recruitment of immune cells into pancreatic islets are poorly defined. Complex interactions involving adhesion molecules, chemokines and chemokine receptors may facilitate this proce
Autor:
Yeqing Angela Yang, Christian Cox, Matthew B. Buechler, Zora Modrusan, Merone Roose-Girma, Rachana N. Pradhan, Roger Caothien, Richard Bourgon, Sören Müller, Amber W. Wang, Akshay T. Krishnamurty, Shannon J. Turley, Aslihan Karabacak Calviello, Joseph R. Arron, Lucinda Tam
Publikováno v:
Nature. 593:575-579
Fibroblasts are non-haematopoietic structural cells that define the architecture of organs, support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer, autoimmunity and wound healing1. Recent studies have described fibrob
Publikováno v:
Cellular and Molecular Neurobiology. 41:129-150
BACKGROUND AND AIM: Thimerosal (THIM) is a mercury-containing preservative widely used in many biological and medical products including many vaccines. It has been accused of being a possible etiological factor for some neurodevelopmental disorders s
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz