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Autor:
K Van Dyk, Sunita K. Patel, J E Carroll, Andrew J. Saykin, Brent J. Small, Danielle Tometich, Traci N. Bethea, Jaeil Ahn, Jeanne S. Mandelblatt, Tim A. Ahles, Deena Graham, Kelly E. Rentscher, Heather S.L. Jim, Brenna C. McDonald, James C. Root, Xingtao Zhou, Harvey J. Cohen, Asma A. Dilawari, Wanting Zhai, Zev M. Nakamura
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
Breast Cancer Research and Treatment
article-version (status) pre
article-version (number) 1
Breast Cancer Research and Treatment
PurposeOlder cancer survivors required medical care during the COVID-19 pandemic despite infection risks, but there are limited data on medical care in this age group. Methods. We evaluated care disruptions in a longitudinal cohort of non-metastatic
Autor:
Martin Bornhäuser, Michael Kramer, Jan-Niklas Eckardt, Christian Thiede, Johannes Schetelig, Karsten Wendt, Ulrich Schuler, Frank Kroschinsky, Jan Moritz Middeke, Katja Sockel, Christoph Röllig, Anas Shekh Sulaiman, Sebastian Riechert, Tim Schmittmann
Publikováno v:
Leukemia
The evaluation of bone marrow morphology by experienced hematopathologists is essential in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of standardization and inter-observer variability. Deep learning (DL) can proces
Autor:
Michael Thomas, Maria Palmisano, Mark Thomas, Sekhar Surapaneni, Yongjun Xue, Mary Liu, Simon Zhou, Rebecca N. Wood-Horrall, Gopal Krishna, Liangang Liu, Leonidas N Carayannopoulos, Ken Ogasawara
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:941-952
Fedratinib, an oral, selective Janus kinase 2 inhibitor, has been shown to inhibit P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter (OCT) 2, and mul
Autor:
Nicholas B. Jennings, Bryan Fellman, Nicole D. Fleming, Wei Hu, Jared K. Burks, Jinsong Liu, Shannon N. Westin, Sara Corvigno, Yanping Zhong, Anil K. Sood
Publikováno v:
J Cancer Res Clin Oncol
PURPOSE: An in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of the immune microenvironment of high-grade serous ovarian cancers (HGSCs) with and without BRCA1 an
Autor:
Bin Zhu, Rachel Lokanga, Natalie Saini, Francisco Martínez-Jiménez, Jung Kim, Kevin M. Brown, Laura Mendoza, Kerstin Heselmeyer-Haddad, Andrea Castro, Mengying Li, Amy Hutchinson, Burcak Otlu, Aaron L Moye, Lucia Anna Muscarella, Nathan Cole, Michael Kebede, Neil E. Caporaso, Scott M. Lawrence, Paul Hofman, Dario Consonni, Manuela Costantini, Naser Ansari-Pour, Hannah Carter, Jonas S Almeida, Yohan Bossé, Maria Luana Poeta, Jian Sang, Bonnie E. Gould Rothberg, Mary E. Olanich, Maria Teresa Landi, Philippe Joubert, Jennifer Rosenbaum, Azhar Khandekar, Thomas Ried, Angela Cecilia Pesatori, Qing Lan, Carla F. Kim, Jiyeon Choi, Douglas R. Stewart, Samuel H. Wilson, Dmitry A. Gordenin, Abel Gonzalez-Perez, Tongwu Zhang, Petra Lenz, Montserrat Garcia-Closas, Nuria Lopez-Bigas, David C. Wedge, Daniela Hirsch, Praphulla M S Bhawsar, Matthew B. Schabath, Yves Pommier, Jianxin Shi, Nathaniel Rothman, Ludmil B. Alexandrov, Máire A. Duggan, S M Ashiqul Islam, Iliana Peneva, Stephen J. Chanock, Wei Zhao, Phuc H Hoang, Leszek J. Klimczak
Publikováno v:
Nat Genet
Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing of 232 LCINS showed 3 subtypes defined by copy number aberrations. The dominant s
Autor:
Masashi Mizumoto, Masahide Matsuda, Toshiyuki Okumura, Haruko Numajiri, Eiichi Ishikawa, Yoshiko Oshiro, Hidehiro Kohzuki, Hideyuki Sakurai, Keiichi Tanaka, Akira Matsumura, Hsiang-Kuang Tony Liang
Publikováno v:
Journal of Cancer Research and Clinical Oncology
BackgroundGlioblastoma peritumoral edema (PE) extent is associated with survival and progression pattern after tumor resection and radiotherapy (RT). To increase tumor control, proton beam was adopted to give high-dose boost (> 90 Gy). However, the c
Autor:
Janice Lu, Pushpinder Kaur, Alexander Ring, Julie E. Lang, Anthony R. Colombo, Irene Kang, Tania B. Porras
Publikováno v:
Br J Cancer
Background Individualising treatment in breast cancer requires effective predictive biomarkers. While relatively few genomic aberrations are clinically relevant, there is a need for characterising patients across different subtypes to identify action
Publikováno v:
Molecular Biotechnology. 64:17-24
Prostate cancer (PCa) is the most popular cancer of mankind. Our study aimed to provide the expression and the predictive significance of miR-1273 g-3p in PCa. Moreover, the effects on cell biological activities were also investigated. The relative e
Autor:
Allan Hackshaw, Karen C. Chung, Joshua J. Ofman, Heidi Reichert, Sarah S. Cohen, Anuraag R. Kansal
Publikováno v:
British Journal of Cancer
Background Multi-cancer early detection (MCED) next-generation-sequencing blood tests represent a potential paradigm shift in screening. Methods We estimated the impact of screening in the US and UK. We used country-specific parameters for uptake, an
Autor:
Hanno M Witte, Svenja Kopelke, Alexander Fürschke, Nikolaus von Bubnoff, Carsten Hackenbroch, Arthur Bauer, Alex Frydrychowicz, Armin Riecke, Britta Mengler, Sebastian Fetscher, Niklas Gebauer
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 148:1789-1801
Background The composition of the tumor microenvironment (TME) is conditioned by immunity and the inflammatory response. Nutritional and inflammation-based risk scores have emerged as relevant predictors of survival outcome across a variety of hemato