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Publikováno v:
Molecular Biology Reports. 48:7147-7152
The promoter region is a key element of gene expression regulation. In mammals, most of the genes present, at the level of their promoter, a large number of islands CpG. Age also is seen as another factor for developing breast cell cancer reaching th
Autor:
Ehsan Sohrabi, Mansoor Khaledi, Hamed Afkhami, Javad Fathi, Masoumeh Moslemi, Ali Zekri, Ehsan Rezaie, Nahid Nafissi
Publikováno v:
Genes & Genomics. 43:1065-1077
Background: Breast cancer (BC) is a common malignancy with a high mortality rate. Malignant cell transformation is associated with metabolic changes. One group pf proteins that are affected are the monocarboxylate transporters (MCTs-SLC16A). The MCTs
Autor:
Yessica C. Martinez, Volker Mai, Maximiliano Tagliamonte, Xuefeng Wang, Maria Ukhanova, Lusine Yaghjyan, Kathleen M. Egan, Shannan N Rich
Publikováno v:
Cancer Causes & Control. 32:681-692
We examined gut microbiome (GM) profiles in relation to mammographic breast density (BD) and body mass index (BMI) in healthy postmenopausal women. Eligible women were postmenopausal, had a BMI ≤ 35 kg/m2, and had not recently taken oral/IV antibio
Autor:
Keltouma Driouch, Sandra Geraci, Michele Iuliani, Philippe Clézardin, Martine Croset, Bruno Vincenzi, Klaus Pantel, Francesco Pantano, Giulia Ribelli, Natalia Bednarz-Knoll, Edith Bonnelye, Daniele Santini, Giuseppe Tonini, Harriet Wikman, Florian Bonin, Sofia Sousa, Saw See Hong, Sonia Simonetti
Publikováno v:
Oncogene
Oncogene, In press, ⟨10.1038/s41388-020-01603-6⟩
Oncogene, Nature Publishing Group, In press, ⟨10.1038/s41388-020-01603-6⟩
Oncogene, In press, ⟨10.1038/s41388-020-01603-6⟩
Oncogene, Nature Publishing Group, In press, ⟨10.1038/s41388-020-01603-6⟩
Bone metastasis remains a major cause of mortality and morbidity in breast cancer. Therefore, there is an urgent need to better select high-risk patients in order to adapt patient’s treatment and prevent bone recurrence. Here, we found that integri
Publikováno v:
Genes & Immunity. 21:380-389
Killer cell immunoglobulin-like receptors (KIR) consists of activating and inhibitory genes are essential for natural killer cell education. To determine the association of KIRs with susceptibility to invasive Breast cancer (BC), genotyping of 16 KIR
Publikováno v:
British Journal of Cancer
Background Breast fibroadenoma (FA) and phyllodes tumour (PT) often have variations of gene mediator complex subunit 12 (MED12) and mutations in the telomerase reverse transcriptase promoter region (TERTp). TERTp mutation is usually tested by Sanger
Publikováno v:
Cancer Causes & Control. 31:1057-1068
Our aim is to examine the associations between high-sensitivity C-reactive protein (hsCRP) and hemoglobin A1c (HbA1c), common biomarkers of inflammation and insulin resistance, respectively, with breast cancer risk, while adjusting for measures of ex
Autor:
Adrienne E Borrie, Diane Logan, Stephen Welch, Nancy Read, Francisco Perera, Yun-Hee Choi, Edward Yu, Jawaid Younus, Finnley A. Rose, Brian Yaremko, Wendy A. Teft, Kylea Potvin, Michael Lock, Tracy Sexton, Richard B. Kim, Theodore A. Vandenberg, John Lenehan, Karin Hahn
Publikováno v:
Breast Cancer Research and Treatment. 183:365-372
Female patients with breast cancer frequently develop arthralgia when treated with aromatase inhibitors (AI). Although the mechanism of AI-induced arthralgia is unknown, potential biomarkers have been identified. The purpose of this study was to inve
Publikováno v:
Breast Cancer Research and Treatment. 183:61-70
Mitochondrial unfolding protein are abundant in breast cancer cells, but the mechanism by which breast cancer cells resist apoptosis is still not fully elucidated. In this study, we explored the role of mitochondrial unfolded protein response (mtUPR)
Autor:
Hye Seon Park, Gyungyub Gong, Hee Jin Lee, Heejae Lee, Young-Ae Kim, Young Ho Kim, Jeong-Han Seo, Hyun Lee
Publikováno v:
Cancer Immunology, Immunotherapy. 69:2381-2391
The clinical significance of adoptive tumor-infiltrating lymphocyte (TIL) therapy has been demonstrated in many clinical trials. We analyzed the in vitro reactivity of cultured TILs against autologous breast cancer cells. TILs and cancer cells were c