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pro vyhledávání: ''
Autor:
Chuan Qin, Dai-Shi Tian, Luo-Qi Zhou, Ke Shang, Liang Huang, Ming-Hao Dong, Yun-Fan You, Jun Xiao, Ying Xiong, Wen Wang, Hao Pang, Jing-Jing Guo, Song-Bai Cai, Di Wang, Chun-Rui Li, Min Zhang, Bi-Tao Bu, Wei Wang
Publikováno v:
Signal Transduction and Targeted Therapy. 8
Chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder (NMOSD). To evalu
Publikováno v:
BMC Cancer. 22
Background Cancer is a major public health problem with pharmacotherapy being the cornerstone of its management. Cancer patients receive multiple drugs concurrently risking Drug-Drug Interactions (DDIs). DDIs, though avoidable, can significantly cont
Publikováno v:
Molecular Biology Reports. 49:531-537
Signal recognition particle (SRP) promotes co-translational translocation of the proteins through or into the endoplasmic reticulum membrane and it also has elongation arrest function. SRP9 is one of the six protein subunits of SRP and functions in e
Autor:
S M Ashiqul Islam, Irina I. Abnizova, James McKay, Yudou He, Estelle Chanudet, Behnoush Abedi-Ardekani, Dariush Nasrollahzadeh, Michael Eden, Alisa M. Goldstein, Jon W. Teague, Blandina T. Mmbaga, Nan Hu, Karl Smith-Byrne, Sandra Perdomo, Jingwei Wang, Christine Carreira, Jean-Yves Scoazec, Rebecca C. Fitzgerald, Luis Felipe Ribeiro, Michael R. Stratton, Samad Gharavi, Sergey Senkin, Erik N Bergstrom, Hiva Saffar, Sarah Moody, Sheila Coelho Soares-Lima, Pauline E Bucciarelli, Stefano Serra, Ghislaine Scelo, Charles Dzamalala, Valerie McCormack, Reza Malekzadeh, Hossein Poustchi, Valerie Gaborieau, Lia S Campos, Joshua R. Atkins, Paul Brennan, Emily Thomas, David T. Jones, Paul Richman, Farid Azmoudeh-Ardalan, Masoud Sotoudeh, Ahmadreza Niavarani, Tatsuhiro Shibata, Calli Latimer, Stephen Fitzgerald, Ludmil B Alexandrov, Ricardo Cortez Cardoso Penha, Abdolreza Fazel, Laura Humphreys, Azhar Khandekar, Arash Nikmanesh, Diana Menya
Publikováno v:
Nature Genetics. 53:1553-1563
Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here w
Publikováno v:
Molecular Biology Reports. 48:7147-7152
The promoter region is a key element of gene expression regulation. In mammals, most of the genes present, at the level of their promoter, a large number of islands CpG. Age also is seen as another factor for developing breast cell cancer reaching th
Autor:
Bin Zhu, Rachel Lokanga, Natalie Saini, Francisco Martínez-Jiménez, Jung Kim, Kevin M. Brown, Laura Mendoza, Kerstin Heselmeyer-Haddad, Andrea Castro, Mengying Li, Amy Hutchinson, Burcak Otlu, Aaron L Moye, Lucia Anna Muscarella, Nathan Cole, Michael Kebede, Neil E. Caporaso, Scott M. Lawrence, Paul Hofman, Dario Consonni, Manuela Costantini, Naser Ansari-Pour, Hannah Carter, Jonas S Almeida, Yohan Bossé, Maria Luana Poeta, Jian Sang, Bonnie E. Gould Rothberg, Mary E. Olanich, Maria Teresa Landi, Philippe Joubert, Jennifer Rosenbaum, Azhar Khandekar, Thomas Ried, Angela Cecilia Pesatori, Qing Lan, Carla F. Kim, Jiyeon Choi, Douglas R. Stewart, Samuel H. Wilson, Dmitry A. Gordenin, Abel Gonzalez-Perez, Tongwu Zhang, Petra Lenz, Montserrat Garcia-Closas, Nuria Lopez-Bigas, David C. Wedge, Daniela Hirsch, Praphulla M S Bhawsar, Matthew B. Schabath, Yves Pommier, Jianxin Shi, Nathaniel Rothman, Ludmil B. Alexandrov, Máire A. Duggan, S M Ashiqul Islam, Iliana Peneva, Stephen J. Chanock, Wei Zhao, Phuc H Hoang, Leszek J. Klimczak
Publikováno v:
Nat Genet
Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing of 232 LCINS showed 3 subtypes defined by copy number aberrations. The dominant s
Autor:
Mohsen, Nabi-Meybodi, Adeleh, Sahebnasagh, Zahra, Hakimi, Masoud, Shabani, Ali Asghar, Shakeri, Fatemeh, Saghafi
Publikováno v:
BMC Cancer. 22
Introduction Radiation therapy is one of the standard methods in the treatment of breast cancer. Radiotherapy-induced dermatitis (RID) is a common complication of radiotherapy (RT) resulting in less tolerance in RT and even discontinuation of treatme
Autor:
Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Jin Lee, Yerang Shin, Youjin Kim, Hyeon-Su Im, Hyeyeong Kim, Su Jin Koh, Young Joo Min, Jae-Cheol Jo, Yunsuk Choi
Publikováno v:
BMC Cancer. 22
BackgroundSevere graft versus host disease (GVHD) is the main reason for non-relapse mortality following allogeneic hematopoietic cell transplantation (HCT). We investigated the serum protein profiles of patients who had undergone HCT to identify pre
Autor:
Agnieszka Paradowska-Gorycka, Ewa Walczuk, Katarzyna Romanowska-Próchnicka, Malgorzata Jaronczyk, L N Sivitskaya, Tomasz Wysocki, Jakub Lach, Anna Wajda, Barbara Stypinska, Danat Yermakovich
Publikováno v:
The Pharmacogenomics Journal
Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis. Nevertheless, MTX resistance is quite a common issue in clinical practice. There are some premises that aryl hydrocarbon receptor (AhR) gene battery may take part in MTX metabolis
Autor:
Kun Zhang, Juntong Wang, Aiwu You, Jun Li, Yuyan Zhang, Guomin Rao, Xuehua Ge, Xuan Liu, Jingshun Gu, Dongchun Wang
Publikováno v:
Genes & Genomics. 43:1157-1165
Gliomas are common malignant tumors in the nervous system, known for poor prognosis and low survival rate. This study aims to explore functions of miR-137 in glioma progression and identify messenger RNAs (mRNA) regulated by miR-137, which provides n