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Autor:
George Rust, Robert Weech-Maldonado, Ferhat D. Zengul, Josué Patien Epané, Luceta McRoy, Zo Ramamonjiarivelo
Publikováno v:
Cancer Causes & Control. 33:321-329
Cancer incidence in the USA remains higher among certain groups, regions, and communities, and there are variations based on nativity. Research has primarily focused on specific groups and types of cancer. This study expands on previous studies to ex
Autor:
Stephanie Burnett, Amit Bahl, Bruno Morgan, Lucy Tregellas, Lisa Pickering, Alastair Thomson, Emma Hall, Tony Elliott, Rachel Slade, Balaji Venugopal, Steve Nicholson, Naveen S. Vasudev, Holly Tovey, Clare Cruickshank, Peter Kirkbride, Alison Hassall, Anita Mitra
Publikováno v:
British Journal of Cancer
Background We investigated the first-line activity of vinflunine in patients with penis cancer. Cisplatin-based combinations are commonly used, but survival is not prolonged; many patients are unfit for such treatment or experience toxicity that outw
Autor:
Fang Fang Zhang, Mengyuan Ruan, Diane M. Harris, Donatus U. Ekwueme, Dariush Mozaffarian, Jaya S. Khushalani, Frederick Cudhea, Zhilei Shan
Publikováno v:
Cancer Causes Control
Purpose: Suboptimal diet is a preventable cause of cancer. We aimed to estimate the economic burden of diet-associated cancer among US adults. Methods: We used a Comparative Risk Assessment model to quantify the number of new cancer cases attributabl
Autor:
Kejia Hu, Lei Deng, Chuanxu Luo, Chengshi Wang, Rulla M. Tamimi, Donghao Lu, Fang Fang, Unnur Valdimarsdóttir, Katja Fall
Publikováno v:
Br J Cancer
BACKGROUND: To assess the risk of cardiovascular mortality among cancer survivors who developed breast cancer as a second malignancy (BCa-2) compared with patients with first primary breast cancer (BCa-1) and the general population. METHODS: Using th
Autor:
Nassim Djebli, Pierre-Olivier Tremblay, Vincent Buchheit, Mario González-Sales, Guillaume Bonnefois, Georgina Meneses-Lorente, Francois Mercier, Nicolas Frey
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:997-1007
Entrectinib (ROZLYTREK®) is a CNS-active, potent, and selective inhibitor of ROS1, TRK A/B/C, and ALK kinase activity. It was recently approved for the treatment of ROS1-positive non-small cell lung cancer and NTRK gene fusion-positive solid tumors.
Autor:
Bin Zhu, Rachel Lokanga, Natalie Saini, Francisco Martínez-Jiménez, Jung Kim, Kevin M. Brown, Laura Mendoza, Kerstin Heselmeyer-Haddad, Andrea Castro, Mengying Li, Amy Hutchinson, Burcak Otlu, Aaron L Moye, Lucia Anna Muscarella, Nathan Cole, Michael Kebede, Neil E. Caporaso, Scott M. Lawrence, Paul Hofman, Dario Consonni, Manuela Costantini, Naser Ansari-Pour, Hannah Carter, Jonas S Almeida, Yohan Bossé, Maria Luana Poeta, Jian Sang, Bonnie E. Gould Rothberg, Mary E. Olanich, Maria Teresa Landi, Philippe Joubert, Jennifer Rosenbaum, Azhar Khandekar, Thomas Ried, Angela Cecilia Pesatori, Qing Lan, Carla F. Kim, Jiyeon Choi, Douglas R. Stewart, Samuel H. Wilson, Dmitry A. Gordenin, Abel Gonzalez-Perez, Tongwu Zhang, Petra Lenz, Montserrat Garcia-Closas, Nuria Lopez-Bigas, David C. Wedge, Daniela Hirsch, Praphulla M S Bhawsar, Matthew B. Schabath, Yves Pommier, Jianxin Shi, Nathaniel Rothman, Ludmil B. Alexandrov, Máire A. Duggan, S M Ashiqul Islam, Iliana Peneva, Stephen J. Chanock, Wei Zhao, Phuc H Hoang, Leszek J. Klimczak
Publikováno v:
Nat Genet
Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing of 232 LCINS showed 3 subtypes defined by copy number aberrations. The dominant s
Autor:
Fei Pang, Fei Shan, Sizhen Wang, Danhua Wang, Xiaofang Xing, Yongning Jia, Fangping Zhao, Honglin Zhu, Tonghui Ma, Ziyu Li, Shuangxi Li, Jiafu Ji
Publikováno v:
Gastric Cancer. 24:1342-1354
Neoadjuvant chemotherapy (NACT) before radical gastrectomy is preferred for locally advanced gastric cancer (GC). However, clinical practices demonstrate that a considerable proportion of GC patients do not benefit from NACT, largely due to the lack
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:3289-3298
Aging is closely related to the occurrence of many diseases, including cancer, and involves changes in the immune microenvironment. γδT cells are important components of resident lymphocytes in mucosal tissues. However, little is known about the ef
Publikováno v:
Gastric Cancer. 24:1194-1202
Early detection of gastric cancer (GC) is a critical step for decreasing mortality. The aim of this study was to evaluate the performance of four prediction models for risk stratification in the screening of GC and precancerous lesions among a large,
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:533-542
Genetic variation in the activation of the prodrug cyclophosphamide (CP) by cytochrome P450 (CYP) enzymes has been shown to influence outcomes. However, CYP are also subject to phenoconversion due to either the effects of comedications or cancer asso